A guide to the composition and functions of the extracellular matrix

NK Karamanos, AD Theocharis, Z Piperigkou… - The FEBS …, 2021 - Wiley Online Library
Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that
provides structural support for the cells and tissues. Accumulated knowledge clearly …

Nanostructured particles assembled from natural building blocks for advanced therapies

Y Ju, H Liao, JJ Richardson, J Guo… - Chemical Society …, 2022 - pubs.rsc.org
Advanced treatments based on immune system manipulation, gene transcription and
regulation, specific organ and cell targeting, and/or photon energy conversion have …

New aspects of vitamin D metabolism and action—Addressing the skin as source and target

D Bikle, S Christakos - Nature Reviews Endocrinology, 2020 - nature.com
Vitamin D has a key role in stimulating calcium absorption from the gut and promoting
skeletal health, as well as many other important physiological functions. Vitamin D is …

[HTML][HTML] CD44: a multifunctional cell surface adhesion receptor is a regulator of progression and metastasis of cancer cells

LT Senbanjo, MA Chellaiah - Frontiers in cell and developmental …, 2017 - frontiersin.org
CD44 is a cell surface adhesion receptor that is highly expressed in many cancers and
regulates metastasis via recruitment of CD44 to the cell surface. Its interaction with …

[HTML][HTML] Role of myeloperoxidase and oxidant formation in the extracellular environment in inflammation-induced tissue damage

CL Hawkins, MJ Davies - Free Radical Biology and Medicine, 2021 - Elsevier
The heme peroxidase family generates a battery of oxidants both for synthetic purposes, and
in the innate immune defence against pathogens. Myeloperoxidase (MPO) is the most …

[HTML][HTML] Cancer metastases: challenges and opportunities

X Guan - Acta pharmaceutica sinica B, 2015 - Elsevier
Cancer metastasis is the major cause of cancer morbidity and mortality, and accounts for
about 90% of cancer deaths. Although cancer survival rate has been significantly improved …

[HTML][HTML] Development and application of hyaluronic acid in tumor targeting drug delivery

Z Luo, Y Dai, H Gao - Acta Pharmaceutica Sinica B, 2019 - Elsevier
Hyaluronic acid (HA) is a natural polysaccharide that has gained much attention due to its
biocompatibility, enzyme degradation capacity and active tumor targeting capacity. Its …

[HTML][HTML] Cancer stem cell functions in hepatocellular carcinoma and comprehensive therapeutic strategies

YC Liu, CT Yeh, KH Lin - Cells, 2020 - mdpi.com
Hepatocellular carcinoma (HCC) is a significant cause of cancer-related mortality owing to
resistance to traditional treatments and tumor recurrence after therapy, which leads to poor …

Hyaluronic acid for anticancer drug and nucleic acid delivery

F Dosio, S Arpicco, B Stella, E Fattal - Advanced drug delivery reviews, 2016 - Elsevier
Hyaluronic acid (HA) is widely used in anticancer drug delivery, since it is biocompatible,
biodegradable, non-toxic, and non-immunogenic; moreover, HA receptors are …

Applications and emerging trends of hyaluronic acid in tissue engineering, as a dermal filler and in osteoarthritis treatment

A Fakhari, C Berkland - Acta biomaterialia, 2013 - Elsevier
Hyaluronic acid (HA) is a naturally occurring biodegradable polymer with a variety of
applications in medicine, including scaffolding for tissue engineering, dermatological fillers …