Serotonin regulates a wide variety of brain functions and behaviors. Here, we synthesize
previous findings that serotonin regulates executive function, sensory gating, and social …

Major depressive disorder (MDD) is a common psychiatric illness with high levels of
morbidity and mortality. Despite intensive research during the past several decades, the …

The incidence of depressive illness is high worldwide, and the inadequacy of currently
available drug treatments contributes to the significant health burden associated with …

Bipolar disorder is a mood disorder characterized by impairing episodes of mania and
depression. Twin studies have established that bipolar disorder is among the most heritable …

The genetic basis of major depressive disorder (MDD) has been investigated extensively,
but the identification of MDD genes has been hampered by conflicting results from …

Serotonin is a major neurotransmitter in the central nervous system (CNS). Dysregulation of
serotonin transmission in the CNS is reported to be related to different psychiatric disorders …

Dysregulation of brain serotonin (5-HT) neurotransmission is thought to underlie mental
conditions as diverse as depression, anxiety disorders, bipolar disorder, autism, and …

Bipolar disorder (BP) is a complex disorder caused by a number of liability genes interacting
with the environment. In recent years, a large number of linkage and association studies …

Aggression, which comprises multi-faceted traits ranging from negative emotionality to
antisocial behaviour, is influenced by an interaction of biological, psychological and social …

Dysregulation of tryptophan hydroxylase (TPH)-dependent serotonin (5-HT) synthesis, has
been implicated in various neuropsychiatric disorders, although the differential expression …