Gene–environment (G× E) interactions contribute to the development of many
neuropsychiatric disorders. Tryptophan hydroxylase-2 (TPH2) synthesizes neuronal …

Background Major depression (MD) results from a complex synergy between genetic and
environmental factors. The aim of this study is to analyze the interaction of tryptophan …

Brain regional serotonin synthesis can be estimated in vivo using positron emission
tomography (PET) and α-[(11) C] methyl-L-tryptophan (11 C-AMT) trapping (K*) as a proxy …

Tryptophan hydroxylase (TPH) catalyses the ratelimiting step in the biosynthesis of
serotonin. In vertebrates, the homologous genes tph1 and tph2 encode two different …

Introduction. Bipolar Disorder (BD) is a serious mood disorder, the aetiology of which is still
unclear. The disorder is characterised by extreme mood variability in which patients fluctuate …

Tryptophan hydroxylase is the rate-limiting enzyme in the biosynthesis of serotonin (5-
hydroxytryptamine; 5-HT). Two isoforms of tryptophan hydroxylase, derived from different …

Purpose: TPH2 and 5-HT2A appear to play vital roles in the homeostatic regulation of
serotonin levels in the brain, their genetic variations may lead to impaired homeostatic …

Bipolar disorder is a severe mental illness that afflicts approximately 1% of the world's
population, and is characterized by mood swings from elation to depression. Although the …

The association of single-nucleotide polymorphisms (SNPs) in the human tryptophan
hydroxylase 2 (TPH2) gene with anxiety traits and depression has been inconclusive …

Recent genome-wide association studies (GWAS) and metaanalyses revealed genetic
associations for ANK3 (ankyrin 3) and CACNA1C (alpha 1C subunit of the L-type voltage …