Lack of an effective drug therapy for abdominal aortic aneurysm

J Golledge, JV Moxon, TP Singh… - Journal of internal …, 2020 - Wiley Online Library
Abdominal aortic aneurysm (AAA) rupture is a common cause of death in adults. Current
AAA treatment is by open surgical or endovascular aneurysm repair. Rodent model and …

[HTML][HTML] Editor's choice--European Society for Vascular Surgery (ESVS) 2024 clinical practice guidelines on the management of abdominal aorto-iliac artery …

A Wanhainen, I Van Herzeele, FB Goncalves… - European Journal of …, 2024 - Elsevier
Abstract Objective The European Society for Vascular Surgery (ESVS) has developed
clinical practice guidelines for the care of patients with aneurysms of the abdominal aorta …

Development of pharmacotherapies for abdominal aortic aneurysms

LM Weaver, CD Loftin, CG Zhan - Biomedicine & Pharmacotherapy, 2022 - Elsevier
The cardiovascular field is still searching for a treatment for abdominal aortic aneurysms
(AAA). This inflammatory disease often goes undiagnosed until a late stage and associated …

Primary care screening for abdominal aortic aneurysm: updated evidence report and systematic review for the US Preventive Services Task Force

JM Guirguis-Blake, TL Beil, CA Senger, EL Coppola - Jama, 2019 - jamanetwork.com
Importance Ruptured abdominal aortic aneurysms (AAAs) have mortality estimated at 81%.
Objective To systematically review the evidence on benefits and harms of AAA screening …

Angiotensin II and leukocyte trafficking: New insights for an old vascular mediator. Role of redox-signaling pathways

L Piqueras, MJ Sanz - Free Radical Biology and Medicine, 2020 - Elsevier
Inflammation and activation of the immune system are key molecular and cellular events in
the pathogenesis of cardiovascular diseases, including atherosclerosis, hypertension …

[HTML][HTML] Current status of the treatment of infrarenal abdominal aortic aneurysms

LJ Wang, AM Prabhakar, CJ Kwolek - … diagnosis and therapy, 2018 - ncbi.nlm.nih.gov
Aortic aneurysms are the 13 th leading cause of death in the United States. While
aneurysms can occur along the entire length of the aorta, the infrarenal location is the most …

[HTML][HTML] Angiotensin-converting enzyme 2, coronavirus disease 2019, and abdominal aortic aneurysms

B Xu, G Li, J Guo, T Ikezoe, K Kasirajan, S Zhao… - Journal of Vascular …, 2021 - Elsevier
Objective Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the etiologic
agent of the current, world-wide coronavirus disease 2019 (COVID-19) pandemic …

Pharmacotherapy in clinical trials for abdominal aortic aneurysms: A systematic review and meta-analysis

Z Su, J Guo, Y Gu - Clinical and Applied Thrombosis …, 2022 - journals.sagepub.com
Objective There is no medical treatment proven to limit abdominal aortic aneurysm (AAA)
progression. This systematic review aimed to summarise available trial evidence on the …

[HTML][HTML] Immune checkpoint programmed death-1 mediates abdominal aortic aneurysm and pseudoaneurysm progression

P Sun, L Zhang, Y Gu, S Wei, Z Wang, M Li… - Biomedicine & …, 2021 - Elsevier
Purpose The causes and pathogenetic mechanisms underlying abdominal aortic aneurysms
(AAAs) and pseudoaneurysms are not fully understood. We hypothesized that inhibiting …

[HTML][HTML] A novel intramural TGF β 1 hydrogel delivery method to decrease murine abdominal aortic aneurysm and rat aortic pseudoaneurysm formation and …

H Bai, P Sun, S Wei, B Xie, M Li, Y Xu, W Wang… - Biomedicine & …, 2021 - Elsevier
Objectives Aneurysms are generally the result of dilation of all 3 layers of the vessel wall,
and pseudoaneurysms are the result of localized extravasation of blood that is contained by …