Cardiac tissue requires a persistent production of energy in order to exert its pumping
function. Therefore, the maintenance of this function relies on mitochondria that represent …

Abstract Organ-on-a-chip (OOC) platforms involve the miniaturization of cell culture systems
and enable a variety of novel experimental approaches. These range from modeling the …

Blood vessels are lined by endothelial cells engaged in distinct organ-specific functions but
little is known about their characteristic gene expression profiles. RNA-Sequencing of the …

Biological self-assembly is crucial in the processes of development, tissue regeneration, and
maturation of bioprinted tissue-engineered constructions. The cell aggregates—spheroids …

In recent years, the development of 3D organoids has opened new avenues of investigation
into development, physiology, and regenerative medicine. Organoid formation and the …

Cardiovascular diseases (CVDs) have been the leading cause of death worldwide during
the past several decades. Cell loss is the main problem that results in cardiac dysfunction …

Cardiomyocyte energy metabolism is altered in heart failure, and primary defects of
metabolic pathways can cause heart failure. Studying cardiac energetics in rodent models …

The adult human heart cannot regain complete cardiac function following tissue injury,
making cardiac regeneration a current clinical unmet need. There are a number of clinical …

Advancements and developments in the 3D bioprinting have been promising and have met
the needs of organ transplantation. Current improvements in tissue engineering constructs …

Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC) are widely used
in in vitro biomedical research and testing. However, fully matured, adult cardiomyocyte …