Anticancer agents that interfere with tubulin functions are widely used in the clinic and have
a broad spectrum of activity against both haematological malignancies and solid tumours …

Peripheral neuropathy is a well recognised treatment-related toxicity in children with cancer,
associated with exposure to neurotoxic chemotherapy agents. Acute damage can occur in …

BACKGROUND Following their previous report on the activity of vinorelbine in the treatment
of rhabdomyosarcoma, the authors report the results of a pilot study aimed at defining the …

Background Antimitotic agents are essential components for curative therapy of pediatric
acute leukemias and many solid tumors. Eribulin is a novel agent that differs from both Vinca …

Sarcomas are a heterogeneous group of neoplasms of mesenchymal origin. Approximately
80% arise from soft tissue and 20% originate from bone. To date more than 100 sarcoma …

AIM: This phase II study evaluated efficacy, safety and pharmacokinetics (PK) profile of
combination intravenous vinorelbine (VNL) and continuous low doses oral …

Soft tissue sarcomas represent a group of heterogeneous mesenchymal tumors that occur
rarely in adults. While a variety of histological subtypes exist, some of the most common are …

The management of progressive unresectable low-grade glioma remains controversial.
Treatment options have included radiotherapy, and more recently chemotherapy, usually …

Background Patients with alveolar rhabdomyosarcoma (ARMS) have inferior outcomes
compared to patients with embryonal rhabdomyosarcoma (ERMS) and more effective …

Maintenance therapy sometimes relies on the use of metronomic chemotherapy (MC); that
is, the continuous administration of low-dose chemotherapy. Maintenance therapy has been …