AIM: To evaluate the synergistic targeting and killing of human hepatocellular carcinoma
(HCC) cells lacking p53 by the oncolytic autonomous parvovirus (PV) H-1 and …

Alternative splicing is associated with human disease. In acute promyelocytic leukaemia
(APL) patients with the long (L)‐type promyelocytic leukaemia‐retinoic acid receptor α fusion …

The tumor suppressor function of the promyelocytic leukemia (PML) protein was first
identified as a result of its dysregulation in acute promyelocytic leukemia, however, its …

The promyelocytic leukaemia protein PML is a growth and tumour suppressor inactivated in
acute promyelocytic leukaemia (APL). Recent evidence indicates that PML plays a tumour …

Since the discovery of Promyelocytic leukemia (PML), this protein has been associated with
the pathogenesis of several hematopoietic malignancies and solid tumors. PML was first …

The tumor suppressor promyelocytic leukemia protein (PML) is located primarily in the
nucleus, where it is the scaffold component of the PML nuclear bodies (PML-NBs). PML-NBs …

The tumor suppressor promyelocytic leukemia protein (PML) is predominantly localized in
the nucleus, where it is essential for the formation and stabilization of the PML nuclear …

Growth arrest, inhibition of cell proliferation, apoptosis, senescence, and differentiation are
the most characterized effects of a given tumor suppressor response. It is becoming …

The first case of acute promyelocytic leukemia presenting as a solitary testicular mass
(myeloid sarcoma) that relapsed in the contralateral testicle is described. The neoplastic …

Defective Fas signaling leads to resistance to various anticancer therapies. Presence of
potential inhibitors of Fas which could block Fas signaling can explain cancer cells …