[HTML][HTML] From Homeostasis to Pathology: Decoding the Multifaceted Impact of Aquaporins in the Central Nervous System

C Toader, CP Tataru, IA Florian… - International journal of …, 2023 - mdpi.com
Aquaporins (AQPs), integral membrane proteins facilitating selective water and solute
transport across cell membranes, have been the focus of extensive research over the past …

[HTML][HTML] Involvement of the glymphatic/meningeal lymphatic system in Alzheimer's disease: insights into proteostasis and future directions

K Yamada, T Iwatsubo - Cellular and Molecular Life Sciences, 2024 - Springer
Background Alzheimer's disease (AD) is pathologically characterized by the abnormal
accumulation of Aβ and tau proteins. There has long been a keen interest among …

Co-administration of dl-3-n-butylphthalide and neprilysin is neuroprotective in Alzheimer disease associated with mild traumatic brain injury.

ZG Wang, A Sharma, L Feng, DF Muresanu… - International Review …, 2023 - europepmc.org
dl-3-n-Butylphthalide is a potent synthetic Chinese celery extract that is highly efficient in
inducing neuroprotection in concussive head injury (CHI), Parkinson's disease, Alzheimer's …

[HTML][HTML] Special Issue “Alzheimer's Disease—115 Years after Its Discovery”

S Cardoso, C Carvalho, SC Correia - Biomedicines, 2024 - mdpi.com
Alzheimer's disease (AD) is a progressive and multifactorial disease that significantly
compromises the lives of millions of people worldwide. Since its first description more than …

[HTML][HTML] Special Issue “Aquaporins in Brain Disease”

M Echevarría, P García-Miranda - International Journal of Molecular …, 2024 - mdpi.com
Water is an abundant and important component of the human brain, the homeostasis of
which is rigorously controlled. Aquaporins (AQPs) play a key role in mediating most water …

[PDF][PDF] Aging brain, dementia and impaired glymphatic pathway: causal relationships

I Shirolapov, A Zakharov, D Smirnova… - Psychiatria …, 2023 - psychiatria-danubina.com
Cellular and molecular processes that are of key importance in the development of
neuroinflammation and increased cytokine response, activation of microglia and …

[PDF][PDF] Aquaporin-4 as the main element of the glymphatic system for clearance of abnormal proteins and prevention of neurodegeneration: a review

I Shirolapov, A Zakharov, S Gochhait, V Pyatin… - age, 2023 - researchgate.net
Background: In the last decade, the concept of the Glymphatic system as a complexly
organized perivascular transport has been formed, it “connects” the cerebrospinal fluid with …

The Implication and Application of Brain Glymphatic System in Multiple Diseases

Y Du, C Yan, Y Wang, Y Xu, X Cun, H Gao - Advanced Therapeutics - Wiley Online Library
The glymphatic system within the central nervous system (CNS) facilitates the exchange and
elimination of cerebrospinal fluid (CSF) and interstitial fluid (ISF), aiding in the removal of …

Glymphatic dysfunction in the pathogenesis of neurodegenerative diseases and pathological aging

IV Shirolapov, AV Zakharov, SV Bulgakova… - Genes & Cells, 2023 - genescells.ru
Recently, the concept of the glymphatic system as a highly organized perivascular network
has been formed, which by hydrodynamic approach, with the key participation of aquaporin …

The Possible Polymicrobial Etiology of Alzheimer's Disease and Related Dementia

RL Landry - 2023 - search.proquest.com
As populations of older Americans grow rapidly and live longer, so too will the number of
individuals living with a neurodegenerative disorder. Neurodegenerative conditions, such as …