Connexins are ubiquitous channel forming proteins that assemble as plasma membrane
hemichannels and as intercellular gap junction channels that directly connect cells. In the …

Inflammation may be caused by a variety of factors and is a hallmark of a plethora of acute
and chronic diseases. The purpose of inflammation is to eliminate the initial cell injury …

Background Postoperative cognitive dysfunction (POCD) is a common complication
following anesthesia and surgery. General anesthetic isoflurane has potential neurotoxicity …

Epilepsies are characterized by recurrent seizures, which disrupt normal brain function.
Alterations in neuronal excitability and excitation-inhibition balance have been shown to …

Gap junctions are specialized cell-to-cell contacts that allow the direct transfer of small
molecules between cells. A single gap junction channel consists of two hemichannels, or …

Despite concerted clinical and research efforts, cancer is a leading cause of death
worldwide. Surgery, radiation, and chemotherapy have remained the most common …

Neuronal signaling in the CNS depends on the microenvironment around synapses and
axons. To prevent fluctuations in blood composition affecting the interstitial fluid and CSF …

Pannexin1 (Panx1) channels are ubiquitously expressed in vertebrate cells and are widely
accepted as adenosine triphosphate (ATP)-releasing membrane channels. Activation of …

Posttranslational modification is a common cellular process that is used by cells to ensure a
particular protein function. This can happen in a variety of ways, eg, from the addition of …

Hypertension is one of the most common risk factors for developing chronic cardiovascular
diseases, including hypertensive nephropathy. Within the glomerulus, hypertension causes …