[HTML][HTML] COVID-19 vaccine update: vaccine effectiveness, SARS-CoV-2 variants, boosters, adverse effects, and immune correlates of protection

WY Chi, YD Li, HC Huang, TEH Chan, SY Chow… - Journal of biomedical …, 2022 - Springer
Abstract Coronavirus Disease 2019 (COVID-19) has been the most severe public health
challenge in this century. Two years after its emergence, the rapid development and …

Efficacy of covid-19 vaccines in immunocompromised patients: systematic review and meta-analysis

ARYB Lee, SY Wong, LYA Chai, SC Lee, MX Lee… - Bmj, 2022 - bmj.com
Objective To compare the efficacy of covid-19 vaccines between immunocompromised and
immunocompetent people. Design Systematic review and meta-analysis. Data sources …

[HTML][HTML] COVID-19 vaccines in patients with cancer: immunogenicity, efficacy and safety

A Fendler, EGE de Vries… - Nature Reviews …, 2022 - nature.com
Patients with cancer have a higher risk of severe coronavirus disease (COVID-19) and
associated mortality than the general population. Owing to this increased risk, patients with …

An update on drugs with therapeutic potential for SARS-CoV-2 (COVID-19) treatment

S Drożdżal, J Rosik, K Lechowicz, F Machaj… - Drug Resistance …, 2021 - Elsevier
The COVID-19 pandemic is one of the greatest threats to human health in the 21st century
with more than 257 million cases and over 5.17 million deaths reported worldwide (as of …

Polymer‐based mRNA delivery strategies for advanced therapies

W Yang, L Mixich, E Boonstra… - Advanced Healthcare …, 2023 - Wiley Online Library
Messenger RNA (mRNA)‐based therapies offer great promise for the treatment of a variety
of diseases. In 2020, two FDA approvals of mRNA‐based vaccines have elevated mRNA …

[HTML][HTML] Fast-track development of vaccines for SARS-CoV-2: the shots that saved the world

VP Chavda, Q Yao, LK Vora, V Apostolopoulos… - Frontiers in …, 2022 - frontiersin.org
In December 2019, an outbreak emerged of severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) which leads to coronavirus disease 2019 (COVID-19). The World Health …

[HTML][HTML] Optimizing COVID-19 vaccination programs during vaccine shortages

K Liu, Y Lou - Infectious Disease Modelling, 2022 - Elsevier
During the ongoing COVID-19 pandemic, vaccine shortages occur due to various types of
constraints, including interruptions in production/supply, higher-than-expected demands …

[HTML][HTML] Longitudinal analysis of anti-SARS-CoV-2 S-RBD IgG antibodies before and after the third dose of the BNT162b2 vaccine

B Lo Sasso, L Agnello, RV Giglio, CM Gambino… - Scientific Reports, 2022 - nature.com
Immunosurveillance by evaluating anti-spike protein receptor-binding domain (S-RBD)
antibodies represents a useful tool to estimate the long immunity against Severe Acute …

[HTML][HTML] Impaired CD4+ T cell response in older adults is associated with reduced immunogenicity and reactogenicity of mRNA COVID-19 vaccination

N Jo, Y Hidaka, O Kikuchi, M Fukahori, T Sawada… - Nature Aging, 2023 - nature.com
Whether age-associated defects in T cells impact the immunogenicity and reactogenicity of
mRNA vaccines remains unclear. Using a vaccinated cohort (n= 216), we demonstrated that …

Study of efficacy and longevity of immune response to third and fourth doses of COVID-19 vaccines in patients with cancer: A single arm clinical trial

A Thakkar, K Pradhan, B Duva, JM Carreno, S Sahu… - Elife, 2023 - elifesciences.org
Background: Cancer patients show increased morbidity with COVID-19 and need effective
immunization strategies. Many healthcare regulatory agencies recommend administering …