Recent evidence suggests that autophagy is a governed catabolic framework enabling the
recycling of nutrients from injured organelles and other cellular constituents via a lysosomal …

Autophagy is an evolutionarily conserved cellular system crucial for cellular homeostasis
that protects cells from a broad range of internal and extracellular stresses. Autophagy …

Autophagy is a fundamental homeostatic process in which certain cellular components are
ingested by double-membrane autophagosomes and then degraded to create energy or to …

Autophagy is a major catabolic degradation and recycling process that maintains
homeostasis in cells and is especially important in postmitotic neurons. We implemented a …

Proteostasis reinforcement is a promising approach in the design of therapeutic
interventions against proteinopathies, including Alzheimer's disease. Understanding how …

Background Ubiquitin–proteasome-system-mediated clearance of misfolded proteins is
essential for cells to maintain proteostasis and reduce the proteotoxicity caused by these …

Prion-like spread of disease-specific tau conformers is a hallmark of all tauopathies. A 19-
residue probe peptide containing a P301L mutation and spanning the R2/R3 splice junction …

Alzheimer's disease (AD) is a severe progressive neurodegenerative condition associated
with neuronal damage and reduced cognitive function that primarily affects the aged …

Autophagy is a globally conserved cellular activity that plays a critical role in maintaining
cellular homeostasis through the breakdown and recycling of cellular constituents. In recent …

Abstract Introduction Neurological diseases, including Alzheimer's, Parkinson's diseases,
and brain cancers, are reportedly caused by genetic aberration and cellular malfunction …