Superparamagnetic iron oxide nanoparticles (SPION) have emerged as an MRI contrast
agent for tumor imaging due to their efficacy and safety. Their utility has been proven in …

Nature is a great source of inspiration in solving extremely complex problems, and it is every
day more common to use its strategies for the development of new materials, methods, and …

Suicide gene therapy is based on the introduction into tumor cells of a viral or a bacterial
gene, which allows the conversion of a non-toxic compound into a lethal drug. Although …

Inflammation is a highly dynamic and complex adaptive process to preserve and restore
tissue homeostasis. Originally viewed as an immune-privileged organ, the central nervous …

This review examines the vast catalytic and therapeutic potential offered by type I (ie oxygen-
insensitive) nitroreductase enzymes in partnership with nitroaromatic prodrugs, with …

The very deep knowledge acquired on the genetics and molecular biology of herpes
simplex virus (HSV), has allowed the development of potential replication-competent and …

Preclinical and clinical tomographic imaging systems increasingly are being utilized for non-
invasive imaging of reporter gene products to reveal the distribution of molecular …

Abstract β-galactosidase plays an important role in early cancer diagnosis and is widely
used in examine transcription and transfection efficiencies. In addition, abnormally …

Beta-galactosidase (β-galactosidase), a lysosomal hydrolytic enzyme, plays a critical role in
the catalytic hydrolysis of glycosidic bonds, leading to the conversion of lactose into …

Theranostics is emerging as a popular strategy for cancer therapy; thanks to the
development of nanotechnology. In this work, we have combined an HSV-TK/GCV suicide …