Autoreactive B cells and interferons are central players in systemic lupus erythematosus
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …

Research elucidating the pathogenesis of systemic lupus erythematosus (SLE) has defined
two critical families of mediators, type I interferon (IFN-I) and autoantibodies targeting nucleic …

Augmented T cell function leading to host damage in autoimmunity is supported by
metabolic dysregulation, making targeting immunometabolism an attractive therapeutic …

Infection is one of the major causes of mortality in patients with systemic lupus
erythematosus (SLE). We previously found that CD38, an ectoenzyme that regulates the …

BACKGROUND Fasting and NAD+-boosting compounds, including NAD+ precursor
nicotinamide riboside (NR), confer antiinflammatory effects. However, the underlying …

The mitochondrion is an intracellular organelle thought to originate from endosymbiosis
between an ancestral eukaryotic cell and an α-proteobacterium. Mitochondria are the …

Patients with end-stage kidney disease (ESKD) are at high risk of severe COVID-19. Here,
we perform longitudinal blood sampling of ESKD haemodialysis patients with COVID-19 …

Adaptive immune responses rely on the proliferation of T lymphocytes able to recognize and
eliminate pathogens. The magnitude and duration of the expansion of activated T cell clones …

There are several autoimmune and rheumatic diseases affecting different organs of the
human body. Multiple sclerosis (MS) mainly affects brain, rheumatoid arthritis (RA) mainly …

B cells orchestrate autoimmune responses in patients with systemic lupus erythematosus
(SLE), but broad-based B cell–directed therapies show only modest efficacy while blunting …