Fast and deep Phosphoproteome analysis with the orbitrap astral mass spectrometer

NM Lancaster, P Sinitcyn, P Forny, TM Peters-Clarke… - bioRxiv, 2023 - biorxiv.org
Owing to its roles in cellular signal transduction, protein phosphorylation plays critical roles
in myriad cell processes. That said, detecting and quantifying protein phosphorylation has …

GestaltMatcher Database-A global reference for facial phenotypic variability in rare human diseases

H Lesmann, A Hustinx, S Moosa, H Klinkhammer… - medRxiv, 2023 - medrxiv.org
The value of computer-assisted image analysis has been shown in several studies. The
performance of tools with artificial intelligence (AI), such as GestaltMatcher, is improved with …

Ligand-induced CaMKIIα hub Trp403 flip, hub domain stacking and kinase inhibition

D Narayanan, ASG Larsen, SJ Gauger, R Adafia… - bioRxiv, 2024 - biorxiv.org
γHydroxybutyric acid (GHB) analogs are small molecules that bind competitively to a specific
cavity in the oligomeric CaMKIIα hub domain. Binding affects conformation and stability of …

GestaltMatcher Database-A global reference for facial phenotypic variability in rare human diseases

TC Hsieh, H Lesmann, A Hustinx, S Moosa, E Marchi… - 2024 - researchsquare.com
The most important factor that complicates the work of dysmorphologists is the significant
phenotypic variability of the human face. Next-Generation Phenotyping (NGP) tools that …