Damage to and degeneration of articular cartilage is a major health issue in industrialized
nations. Articular cartilage has a particularly limited capacity for auto regeneration. At …

There is an urgent demand for long term solutions to improve osteoarthritis treatments in the
ageing population. There are drugs that control the pain but none that stop the progression …

Chondrocytes are influenced by mechanical forces to remodel cartilage extracellular matrix.
Previous studies have demonstrated the effects of mechanical forces on changes in …

Activation and disruption of Wnt/β-catenin signaling both result in cartilage breakdown via
unknown mechanisms. Here we show that both WNT-3A and the Wnt inhibitor DKK1 …

This study explored the biologic response of chondrocytes and mesenchymal stem cells
(MSCs) to a dynamic mechanical loading regime. We developed a time-efficient …

Temporomandibular joint (TMJ), a site that is often impacted by osteoarthritis (OA), is
biomechanically linked with dental occlusion. Tissue responses in TMJ condyle to …

Objective To assess whether the association of genetic polymorphisms with osteoarthritis
(OA) in other populations could be replicated in a large, multicenter, mixed‐sex, case …

Sox9 is a transcription factor that is essential for chondrocyte differentiation and chondrocyte-
specific gene expression. However, the precise mechanism of Sox9 activation during …

Mechanical loading of articular cartilage stimulates the metabolism of resident chondrocytes
and induces the synthesis of molecules to maintain the integrity of the cartilage. Mechanical …

Recent investigations into the striking heterogeneity of cellular reaction patterns that are
characteristic for, and puzzling in, osteoarthritic cartilage degeneration addressed apoptotic …