Pharmacotherapeutic aspects of unfractionated and low molecular weight heparins

M Verstraete - Drugs, 1990 - Springer
Standard unfractionated heparin is a mixture of mucopolysaccharide chains of various
length that may vary from 5000 to 30000 daltons. Heparin is only effective as an …

Epidemiology of coagulation disorders

AC Nathwani, EGD Tuddenham - Baillière's clinical haematology, 1992 - Elsevier
Haemostasis is the arrest of haemorrhage at sites of vascular injury by various means,
including clot formation and platelet aggregation, with subsequent restoration of perfusion …

Prevention of deep vein thrombosis in neurosurgical patients: a controlled, randomized trial of external pneumatic compression boots

JJ Skillman, REC Collins, NP Coe, BS Goldstein… - Surgery, 1978 - surgjournal.com
A prospective, randomized clinical trial in 95 patients undergoing neurosurgical operative
procedures was performed to investigate the efficacy of external pneumatic compression …

[图书][B] Postoperative thromboembolism: frequency, etiology, prophylaxis

D Bergqvist - 2012 - books.google.com
Our knowledge of postoperative thromboembolic complications has increased enormously
over the past 2 decades, particularly where diag nosis and prophylaxis are concerned. The …

Prevention of deep vein thrombosis in urological patients: a controlled, randomized trial of low-dose heparin and external pneumatic compression boots

NP Coe, REC Collins, LA Klein, MA Bettmann… - Surgery, 1978 - surgjournal.com
A prospective, randomized clinical trial in 83 patients undergoing open urological operations
was performed to compare the relative prophylactic efficacy of low-dose heparin and …

From heparins to factor Xa inhibitors and beyond

S Alban - European Journal of Clinical Investigation, 2005 - Wiley Online Library
Despite some disadvantages, unfractionated heparin (UFH) and oral anticoagulants have
been the only anticoagulants for prophylaxis and therapy of thromboembolic disorders for …

A novel anti-thrombotic heparinoid (Org 10172) devoid of bleeding inducing capacity: a survey of its pharmacological properties in experimental animal models

DG Meuleman, PMJ Hobbelen, G Van Dedem… - Thrombosis …, 1982 - Elsevier
The pharmacological profile of Org 10172, a mixture of sulphated glycosaminoglycorunans
derived from hog intestinal mucosa, has been assessed in experimental thrombosis and …

Epidemiology and pathogenesis of venous thrombosis

J Hirsh, RD Hull, GE Raskob - Journal of the American College of …, 1986 - Elsevier
Venous thrombi are intravascular deposits composed predominantly of fibrin and red blood
cells with a variable platelet and leukocyte component. They frequently arise in large venous …

Pharmacological alterations in the clotting mechanism: Use in microvascular surgery

LD Ketchum - The Journal of Hand Surgery, 1978 - Elsevier
At the present time there is confusion as to what pharmacological adjuncts are helpful
toward increasing patency rates of microvascular repairs. To select a drug rationally, an …

Intrapulmonary heparin: A new procedure for anticoagulant therapy

LB Jaques, J Mahadoo, LW Kavanagh - The Lancet, 1976 - Elsevier
Heparin was administered by the intrapulmonary route to dogs, mice, rats, and human
volunteers. In all species, a single administration of a large quantity of heparin via the lung …