Abstract Since Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was
identified in late 2019, the coronavirus disease 2019 (COVID-19) pandemic has challenged …

Goetting, V., Lee, KA, Tell, LA Pharmacokinetics of veterinary drugs in laying hens and
residues in eggs: a review of the literature. J. vet. Pharmacol. Therap. 34, 521–556. Poultry …

1 SQ109 is a novel [1, 2]‐diamine‐based ethambutol (EMB) analog developed from high‐
throughput combinatorial screening. The present study aimed at characterizing its …

Poor skin wound healing, which is common in patients with diabetes, is related to
imbalanced macrophage polarization. Here, we find that nutrition sensor GCN2 (general …

PURPOSE: Halofuginone (tempostatin™) is a synthetic derivative of a quinazolinone
alkaloid showing anti-angiogenic, anti-metastatic and anti-proliferative effects in preclinical …

Background and Purpose Halofuginone is a febrifugine derivative originally isolated from
Chinese traditional herb Chang Shan that exhibits anti‐hypertrophic, anti‐fibrotic and anti …

Fibrosis, which can be defined as an abnormal or excessive accumulation of extracellular
matrix (ECM), particularly fibrillar collagens, is a key driver of progressive organ dysfunction …

We identify the prolyl-tRNA synthetase (PRS) inhibitor halofuginone, a compound in clinical
trials for anti-fibrotic and anti-inflammatory applications, as a potent inhibitor of SARS-CoV-2 …

Objective Tissue fibrosis is a major cause of morbidity and mortality in systemic sclerosis
(SSc), and an increasing number of promising molecular targets for antifibrotic therapies …

Background The amino acid response (AAR) is an evolutionarily conserved protective
mechanism activated by amino acid deficiency through a key kinase, general control …