Chitosan nanoparticles as a promising tool in nanomedicine with particular emphasis on oncological treatment

J Sharifi-Rad, C Quispe, M Butnariu, LS Rotariu… - Cancer cell …, 2021 - Springer
The study describes the current state of knowledge on nanotechnology and its utilization in
medicine. The focus in this manuscript was on the properties, usage safety, and potentially …

Chitosan on the surface of nanoparticles for enhanced drug delivery: A comprehensive review

MH Elkomy, AA Ali, HM Eid - Journal of Controlled Release, 2022 - Elsevier
The ability of chitosan (CTS) to promote mucoadhesion, trigger positive/negative surface
interactions, and open tight junctions has inspired researchers to coat lipid-based and …

Brain targeted delivery of carmustine using chitosan coated nanoparticles via nasal route for glioblastoma treatment

S Ahmad, I Khan, J Pandit, NA Emad, S Bano… - International Journal of …, 2022 - Elsevier
This study aims to develop chitosan-coated PLGA nanoparticles intended for nose-to-brain
delivery of carmustine. Formulations were prepared by the double emulsion solvent …

Intranasal nanotherapeutics for brain targeting and clinical studies in Parkinson's disease

P Saha, H Kathuria, MM Pandey - Journal of Controlled Release, 2023 - Elsevier
Parkinson's disease (PD) is the second leading neurodegenerative disease globally,
impacting the quality of life of millions of people. It is estimated that the treatment cost of PD …

Nanomaterials for drug delivery to the central nervous system

DM Teleanu, I Negut, V Grumezescu, AM Grumezescu… - Nanomaterials, 2019 - mdpi.com
The intricate microstructure of the blood-brain barrier (BBB) is responsible for the accurate
intrinsic regulation of the central nervous system (CNS), in terms of neuronal …

Brain drug delivery and neurodegenerative diseases: Polymeric PLGA-based nanoparticles as a forefront platform

M Pinto, V Silva, S Barreiro, R Silva, F Remião… - Ageing Research …, 2022 - Elsevier
The discovery of effective drugs for the treatment of neurodegenerative disorders (NDs) is a
deadlock. Due to their complex etiology and high heterogeneity, progresses in the …

Brain-targeted intranasal delivery of dopamine with borneol and lactoferrin co-modified nanoparticles for treating Parkinson's disease

S Tang, A Wang, X Yan, L Chu, X Yang, Y Song… - Drug Delivery, 2019 - Taylor & Francis
Efficient delivery of brain-targeted drugs is highly important for successful therapy in
Parkinson's disease (PD). This study was designed to formulate borneol and lactoferrin co …

PLGA's plight and the role of stealth surface modification strategies in its use for intravenous particulate drug delivery

VV Sheffey, EB Siew, EEL Tanner… - Advanced …, 2022 - Wiley Online Library
Numerous human disorders can benefit from targeted, intravenous (IV) drug delivery.
Polymeric nanoparticles have been designed to undergo systemic circulation and deliver …

[HTML][HTML] Polymeric nanocarriers for nose-to-brain drug delivery in neurodegenerative diseases and neurodevelopmental disorders

R Awad, A Avital, A Sosnik - Acta Pharmaceutica Sinica B, 2023 - Elsevier
Neurodegenerative diseases are progressive conditions that affect the neurons of the
central nervous system (CNS) and result in their damage and death. Neurodevelopmental …

Recent advances in PLGA based nanocarriers for drug delivery system: a state of the art review

SR Pardeshi, A Nikam, P Chandak… - … Journal of Polymeric …, 2023 - Taylor & Francis
The biomolecules in the clinical use being delivered by the conventional mode of delivery
often exhibit poor affinity. So, there is a need for a nanomedicine-based approach that could …