Polypharmacology describes the activity of compounds at multiple targets. Current research
focuses on two aspects of polypharmacology:(1) unintended polypharmacology can lead to …

Heart rhythm disorders, arrhythmias, place a huge economic burden on society and have a
large impact on the quality of life of a vast number of people. Arrhythmias can have genetic …

Drugs targeting atrial‐specific ion channels, Kv1. 5 or Kir3. 1/3.4, are being developed as
new therapeutic strategies for atrial fibrillation. However, current preclinical studies carried …

Spirophyllines A–D (1–4), four new spirooxindole alkaloids all characterized by the spiro
[pyrrolidin-3, 3′-oxindole] core and a rare isoxazolidine ring, were isolated from Uncaria …

Introduction: Atrial fibrillation (AF) is the most common cardiac arrhythmia. Consequently,
novel therapies are being developed. Ultimately, the impact of compounds on the action …

Background and Purpose Inhibition of the G‐protein gated ACh‐activated inward rectifier
potassium current, IK, ACh may be an effective atrial selective treatment strategy for atrial …

Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia and has a significant impact on
morbidity and mortality. Current antiarrhythmic drugs for AF suffer from limited safety and …

Among the large number of potassium-channel families implicated in the control of neuronal
excitability, G-protein-gated inwardly rectifying potassium channels (GIRK/Kir3) have been …

Stimulation of the vagal nerve slows the heart rate and leads to shorter action potential
duration in the atria. These effects are mainly mediated by binding of the vagal …

Atrial fibrillation (AF), the most frequent cardiac arrhythmia, is associated with increased
morbidity and mortality. 1 Currently available pharmacologic interventions for AF have major …