Primary structure of glycans by NMR spectroscopy

C Fontana, G Widmalm - Chemical Reviews, 2023 - ACS Publications
Glycans, carbohydrate molecules in the realm of biology, are present as biomedically
important glycoconjugates and a characteristic aspect is that their structures in many …

[HTML][HTML] Targeting the holy triangle of quorum sensing, biofilm formation, and antibiotic resistance in pathogenic bacteria

RV Sionov, D Steinberg - Microorganisms, 2022 - mdpi.com
Chronic and recurrent bacterial infections are frequently associated with the formation of
biofilms on biotic or abiotic materials that are composed of mono-or multi-species cultures of …

Physiological functions of bacterial “multidrug” efflux pumps

PJF Henderson, C Maher, LDH Elbourne… - Chemical …, 2021 - ACS Publications
Bacterial multidrug efflux pumps have come to prominence in human and veterinary
pathogenesis because they help bacteria protect themselves against the antimicrobials …

β-Lactams against the Fortress of the Gram-Positive Staphylococcus aureus Bacterium

JF Fisher, S Mobashery - Chemical reviews, 2020 - ACS Publications
The biological diversity of the unicellular bacteria—whether assessed by shape, food,
metabolism, or ecological niche—surely rivals (if not exceeds) that of the multicellular …

[HTML][HTML] Bacterial Targets of Antibiotics in Methicillin-Resistant Staphylococcus aureus

H Lade, JS Kim - Antibiotics, 2021 - mdpi.com
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most prevalent bacterial
pathogens and continues to be a leading cause of morbidity and mortality worldwide. MRSA …

[HTML][HTML] Isolation, characterization, and docking studies of campesterol and β-sitosterol from Strychnos innocua (Delile) root bark

AJ Uttu, MS Sallau, H Ibrahim, ORA Iyun - Journal of Taibah University …, 2023 - Elsevier
Objectives Phytosterols obtained from medicinal plants are well known for their anti-diabetic,
anti-cardiovascular, anti-cancer, and anti-microbial properties. Strychnos innocua (a …

[HTML][HTML] Breaking down the cell wall: Still an attractive antibacterial strategy

J Zhou, Y Cai, Y Liu, H An, K Deng, MA Ashraf… - Frontiers in …, 2022 - frontiersin.org
Since the advent of penicillin, humans have known about and explored the phenomenon of
bacterial inhibition via antibiotics. However, with changes in the global environment and the …

Glycoconjugate vaccines against antimicrobial resistant pathogens

C Sorieul, M Dolce, MR Romano, J Codée… - Expert Review of …, 2023 - Taylor & Francis
Introduction Antimicrobial resistance (AMR) is responsible for the death of millions
worldwide and stands as a major threat to our healthcare systems, which are heavily reliant …

[HTML][HTML] Systems biology elucidates the distinctive metabolic niche filled by the human gut microbe Eggerthella lenta

C Noecker, J Sanchez, JE Bisanz, V Escalante… - PLoS …, 2023 - journals.plos.org
Human gut bacteria perform diverse metabolic functions with consequences for host health.
The prevalent and disease-linked Actinobacterium Eggerthella lenta performs several …

C1q binding to surface-bound IgG is stabilized by C1r2s2 proteases

SA Zwarthoff, K Widmer, A Kuipers… - Proceedings of the …, 2021 - National Acad Sciences
Complement is an important effector mechanism for antibody-mediated clearance of
infections and tumor cells. Upon binding to target cells, the antibody's constant (Fc) domain …