Calcium signalling in Cajal-like interstitial cells of the lower urinary tract

BT Drumm, SD Koh, KE Andersson, SM Ward - Nature reviews Urology, 2014 - nature.com
Interstitial cells of Cajal (ICC) serve several critical physiological roles in visceral smooth
muscle organs, including acting as electrical pacemakers to modulate phasic contractile …

New therapeutic targets to prevent benign prostatic enlargement and symptomatic progression to benign prostatic obstruction—ICI‐RS 2023

A Kanai, B Chakrabarty, M Winder… - Neurourology and …, 2023 - Wiley Online Library
Aims Benign prostatic enlargement (BPE) can impact lower urinary tract function due to its
potential progression to benign prostatic obstruction (BPO). Treatment options include …

[HTML][HTML] Oxytocin receptor antagonists as a novel pharmacological agent for reducing smooth muscle tone in the human prostate

SN Lee, J Kraska, M Papargiris, L Teng, B Niranjan… - Scientific reports, 2021 - nature.com
Pharmacotherapies for the treatment of Benign Prostatic Hyperplasia (BPH) are targeted at
reducing cellular proliferation (static component) or reducing smooth muscle tone (dynamic …

[HTML][HTML] Age related differences in responsiveness to sildenafil and tamsulosin are due to myogenic smooth muscle tone in the human prostate

SN Lee, B Chakrabarty, B Wittmer, M Papargiris… - Scientific Reports, 2017 - nature.com
Lower urinary tract symptoms (LUTS) due to Benign Prostatic Hyperplasia (BPH) are highly
prevalent in older men, having a profound impact on patient quality of life. Current …

[HTML][HTML] The Effects of Age on Prostatic Responses to Oxytocin and the Effects of Antagonists

M Badshah, J Ibrahim, N Su, P Whiley, M Whittaker… - Biomedicines, 2023 - mdpi.com
Benign prostatic hyperplasia (BPH) is an age-related enlargement of the prostate with
urethral obstruction that predominantly affects the middle-aged and older male population …

[HTML][HTML] Age-Dependent Effects of Oxytocin and Oxytocin Receptor Antagonists on Bladder Contractions: Implications for the Treatment of Overactive Bladder …

M Badshah, J Ibrahim, N Su, P Whiley, R Middendorff… - Biomedicines, 2024 - mdpi.com
Overactive bladder (OAB) is an age-related disorder characterised by unstable bladder
contractions resulting in disruptive lower urinary tract symptoms (LUTS), thus creating a …

Generation and regulation of spontaneous contractions in the prostate

B Chakrabarty, S Lee, B Exintaris - Smooth Muscle Spontaneous Activity …, 2019 - Springer
Spontaneous myogenic contractions have been shown to be significantly upregulated in
prostate tissue collected from men with Benign Prostatic Hyperplasia (BPH), an extremely …

Role of prostatic interstitial cells in prostate motility

RJ Lang, H Hashitani - Journal of Smooth Muscle Research, 2017 - jstage.jst.go.jp
The prostate is a gland whose secretions contribute to the seminal fluids ejaculated upon
activation of autonomic sympathetic nerves. In elder males, the prostate undergoes an …

A novel application of three phase hollow fiber based liquid phase microextraction (HF-LPME) for the HPLC determination of tamsulosin from biological fluids

RA Afshari, M Qomi - Current Pharmaceutical Analysis, 2016 - ingentaconnect.com
Background: Tamsulosin is used for the treatment of difficult urination, a common symptom
of an enlarged prostate. Objective: In the present paper, for the first time a microextraction …

[PDF][PDF] The Effects of Age on Prostatic Responses to Oxytocin and the Effects of Antagonists. Biomedicines 2023, 11, 2956

M Badshah, J Ibrahim, N Su, P Whiley, M Whittaker… - 2023 - academia.edu
Benign prostatic hyperplasia (BPH) is an age-related enlargement of the prostate with
urethral obstruction that predominantly affects the middle-aged and older male population …