Calcium signalling in Cajal-like interstitial cells of the lower urinary tract
Interstitial cells of Cajal (ICC) serve several critical physiological roles in visceral smooth
muscle organs, including acting as electrical pacemakers to modulate phasic contractile …
muscle organs, including acting as electrical pacemakers to modulate phasic contractile …
New therapeutic targets to prevent benign prostatic enlargement and symptomatic progression to benign prostatic obstruction—ICI‐RS 2023
A Kanai, B Chakrabarty, M Winder… - Neurourology and …, 2023 - Wiley Online Library
Aims Benign prostatic enlargement (BPE) can impact lower urinary tract function due to its
potential progression to benign prostatic obstruction (BPO). Treatment options include …
potential progression to benign prostatic obstruction (BPO). Treatment options include …
[HTML][HTML] Oxytocin receptor antagonists as a novel pharmacological agent for reducing smooth muscle tone in the human prostate
SN Lee, J Kraska, M Papargiris, L Teng, B Niranjan… - Scientific reports, 2021 - nature.com
Pharmacotherapies for the treatment of Benign Prostatic Hyperplasia (BPH) are targeted at
reducing cellular proliferation (static component) or reducing smooth muscle tone (dynamic …
reducing cellular proliferation (static component) or reducing smooth muscle tone (dynamic …
[HTML][HTML] Age related differences in responsiveness to sildenafil and tamsulosin are due to myogenic smooth muscle tone in the human prostate
SN Lee, B Chakrabarty, B Wittmer, M Papargiris… - Scientific Reports, 2017 - nature.com
Lower urinary tract symptoms (LUTS) due to Benign Prostatic Hyperplasia (BPH) are highly
prevalent in older men, having a profound impact on patient quality of life. Current …
prevalent in older men, having a profound impact on patient quality of life. Current …
[HTML][HTML] The Effects of Age on Prostatic Responses to Oxytocin and the Effects of Antagonists
Benign prostatic hyperplasia (BPH) is an age-related enlargement of the prostate with
urethral obstruction that predominantly affects the middle-aged and older male population …
urethral obstruction that predominantly affects the middle-aged and older male population …
[HTML][HTML] Age-Dependent Effects of Oxytocin and Oxytocin Receptor Antagonists on Bladder Contractions: Implications for the Treatment of Overactive Bladder …
Overactive bladder (OAB) is an age-related disorder characterised by unstable bladder
contractions resulting in disruptive lower urinary tract symptoms (LUTS), thus creating a …
contractions resulting in disruptive lower urinary tract symptoms (LUTS), thus creating a …
Generation and regulation of spontaneous contractions in the prostate
B Chakrabarty, S Lee, B Exintaris - Smooth Muscle Spontaneous Activity …, 2019 - Springer
Spontaneous myogenic contractions have been shown to be significantly upregulated in
prostate tissue collected from men with Benign Prostatic Hyperplasia (BPH), an extremely …
prostate tissue collected from men with Benign Prostatic Hyperplasia (BPH), an extremely …
Role of prostatic interstitial cells in prostate motility
RJ Lang, H Hashitani - Journal of Smooth Muscle Research, 2017 - jstage.jst.go.jp
The prostate is a gland whose secretions contribute to the seminal fluids ejaculated upon
activation of autonomic sympathetic nerves. In elder males, the prostate undergoes an …
activation of autonomic sympathetic nerves. In elder males, the prostate undergoes an …
A novel application of three phase hollow fiber based liquid phase microextraction (HF-LPME) for the HPLC determination of tamsulosin from biological fluids
RA Afshari, M Qomi - Current Pharmaceutical Analysis, 2016 - ingentaconnect.com
Background: Tamsulosin is used for the treatment of difficult urination, a common symptom
of an enlarged prostate. Objective: In the present paper, for the first time a microextraction …
of an enlarged prostate. Objective: In the present paper, for the first time a microextraction …
[PDF][PDF] The Effects of Age on Prostatic Responses to Oxytocin and the Effects of Antagonists. Biomedicines 2023, 11, 2956
Benign prostatic hyperplasia (BPH) is an age-related enlargement of the prostate with
urethral obstruction that predominantly affects the middle-aged and older male population …
urethral obstruction that predominantly affects the middle-aged and older male population …