Ex-vivo Kidney Machine Perfusion: Therapeutic Potential
R Zulpaite, P Miknevicius, B Leber, K Strupas… - Frontiers in …, 2021 - frontiersin.org
Kidney transplantation remains the gold standard treatment for patients suffering from end-
stage kidney disease. To meet the constantly growing organ demands grafts donated after …
stage kidney disease. To meet the constantly growing organ demands grafts donated after …
[HTML][HTML] Perfusate Composition and Duration of Ex-Vivo Normothermic Perfusion in Kidney Transplantation: A Systematic Review
Ex-vivo normothermic perfusion (EVNP) is an emerging strategy in kidney preservation that
enables resuscitation and viability assessment under pseudo-physiological conditions prior …
enables resuscitation and viability assessment under pseudo-physiological conditions prior …
Controlled oxygenated rewarming as novel end‐ischemic therapy for cold stored liver grafts. A randomized controlled trial
T Minor, C von Horn, H Zlatev, F Saner… - Clinical and …, 2022 - Wiley Online Library
Abrupt return to normothermia has been shown a genuine factor contributing to graft
dysfunction after transplantation. This study tested the concept to mitigate reperfusion injury …
dysfunction after transplantation. This study tested the concept to mitigate reperfusion injury …
Clinical use of controlled oxygenated rewarming of kidney grafts prior to transplantation by ex vivo machine perfusion. A pilot study
H Zlatev, C von Horn, M Kaths, A Paul… - European Journal of …, 2022 - Wiley Online Library
Background Sudden restoration of normothermic conditions upon reperfusion of cold‐stored
grafts has been suggested to entail a massive energy demand not yet met by the cells that …
grafts has been suggested to entail a massive energy demand not yet met by the cells that …
Normothermic machine perfusion of kidneys: current strategies and future perspectives
F Messner, C Bogensperger, JP Hunter… - Current opinion in …, 2022 - journals.lww.com
Normothermic machine perfusion of kidneys: current strategie... : Current Opinion in Organ
Transplantation Normothermic machine perfusion of kidneys: current strategies and future …
Transplantation Normothermic machine perfusion of kidneys: current strategies and future …
Role of perfusion medium in rewarming machine perfusion from hypo‐to normothermia
C von Horn, B Lüer, L Malkus, T Minor - Artificial Organs, 2024 - Wiley Online Library
Background Gradual warming up of cold stored organ grafts using a controlled machine
perfusion protocol facilitates restitution of cellular homeostasis and mitigates rewarming …
perfusion protocol facilitates restitution of cellular homeostasis and mitigates rewarming …
Advances in hypothermic and normothermic perfusion in kidney transplantation
TB Smith, ML Nicholson, SA Hosgood - Transplantology, 2021 - mdpi.com
Hypothermic and normothermic machine perfusion in kidney transplantation are purported
to exert a beneficial effect on post-transplant outcomes compared to the traditionally used …
to exert a beneficial effect on post-transplant outcomes compared to the traditionally used …
Preservation of mitochondrial coupling and renal function by controlled oxygenated rewarming of porcine kidney grafts
H Zlatev, C von Horn, T Minor - Biomolecules, 2021 - mdpi.com
Background: Warm reperfusion after previous cold storage has been shown to have a
negative impact on mitochondrial function of organ grafts. Here, we wanted to investigate …
negative impact on mitochondrial function of organ grafts. Here, we wanted to investigate …
Effect of Subnormothermic Machine Perfusion on the Preservation of Vascularized Composite Allografts After Prolonged Warm Ischemia
L Charlès, IF von Reiterdank, HH Lancia… - …, 2024 - journals.lww.com
Background. Warm ischemia time (WIT) and ischemia–reperfusion injury are limiting factors
for vascularized composite allograft (VCA) transplantation. Subnormothermic machine …
for vascularized composite allograft (VCA) transplantation. Subnormothermic machine …
External pressure dynamics promote kidney viability and perfusate filtration during ex vivo kidney perfusion
Y Higashi, J Homma, H Sekine, H Yago… - Scientific Reports, 2022 - nature.com
Normothermic machine perfusion (NMP) has not yet been established as a technique for
preserving organs for a day. A key contributing factor to the same is that the perfusing …
preserving organs for a day. A key contributing factor to the same is that the perfusing …