Ion channels in cancer: are cancer hallmarks oncochannelopathies?
N Prevarskaya, R Skryma, Y Shuba - Physiological reviews, 2018 - journals.physiology.org
Genomic instability is a primary cause and fundamental feature of human cancer. However,
all cancer cell genotypes generally translate into several common pathophysiological …
all cancer cell genotypes generally translate into several common pathophysiological …
[HTML][HTML] Targeting calcium signaling in cancer therapy
C Cui, R Merritt, L Fu, Z Pan - Acta pharmaceutica sinica B, 2017 - Elsevier
The intracellular calcium ions (Ca 2+) act as second messenger to regulate gene
transcription, cell proliferation, migration and death. Accumulating evidences have …
transcription, cell proliferation, migration and death. Accumulating evidences have …
[HTML][HTML] Valosin-containing protein (VCP)/p97: a prognostic biomarker and therapeutic target in cancer
S Costantini, F Capone, A Polo, P Bagnara… - International journal of …, 2021 - mdpi.com
Valosin-containing protein (VCP)/p97, a member of the AAA+ ATPase family, is a molecular
chaperone recruited to the endoplasmic reticulum (ER) membrane by binding to membrane …
chaperone recruited to the endoplasmic reticulum (ER) membrane by binding to membrane …
[HTML][HTML] Calcium permeable channels in cancer hallmarks
S Tajada, C Villalobos - Frontiers in pharmacology, 2020 - frontiersin.org
Cancer, the second cause of death worldwide, is characterized by several common criteria,
known as the “cancer hallmarks” such as unrestrained cell proliferation, cell death …
known as the “cancer hallmarks” such as unrestrained cell proliferation, cell death …
Calcium-based nanotechnology for cancer therapy
Y Kang, L Xu, J Dong, Y Huang, X Yuan, R Li… - Coordination Chemistry …, 2023 - Elsevier
Ions are the cornerstones of various biological functions and have been widely used for
tumor therapy, called ion interference therapy (IIT). Calcium ion (Ca 2+) is one of the most …
tumor therapy, called ion interference therapy (IIT). Calcium ion (Ca 2+) is one of the most …
Repurposing drugs targeting metabolic diseases for cancer therapeutics
Highlights•Discovery of new drugs against cancer is of utmost importance.•Drug repurposing
is an alternative approach to traditional drug discovery.•It significantly reduces the R&D …
is an alternative approach to traditional drug discovery.•It significantly reduces the R&D …
[HTML][HTML] Pharmacological targeting of ion channels for cancer therapy: in vivo evidences
L Leanza, A Manago, M Zoratti, E Gulbins… - Biochimica et Biophysica …, 2016 - Elsevier
Since the discovery of the participation of various ion channels in the regulation of cell
proliferation and programmed cell death two decades ago, the field exploring ion channel …
proliferation and programmed cell death two decades ago, the field exploring ion channel …
[HTML][HTML] Role of ion channels in gastrointestinal cancer
KJ Anderson, RT Cormier, PM Scott - World Journal of …, 2019 - ncbi.nlm.nih.gov
In their seminal papers Hanahan and Weinberg described oncogenic processes a normal
cell undergoes to be transformed into a cancer cell. The functions of ion channels in the …
cell undergoes to be transformed into a cancer cell. The functions of ion channels in the …
[HTML][HTML] Potassium channel-driven bioelectric signalling regulates metastasis in triple-negative breast cancer
Background There is a critical need to better understand the mechanisms that drive local cell
invasion and metastasis to develop new therapeutics targeting metastatic disease …
invasion and metastasis to develop new therapeutics targeting metastatic disease …
[HTML][HTML] Endogenous bioelectrics in development, cancer, and regeneration: drugs and bioelectronic devices as electroceuticals for regenerative medicine
A major frontier in the post-genomic era is the investigation of the control of coordinated
growth and three-dimensional form. Dynamic remodeling of complex organs in regulative …
growth and three-dimensional form. Dynamic remodeling of complex organs in regulative …