Genomic instability is a primary cause and fundamental feature of human cancer. However,
all cancer cell genotypes generally translate into several common pathophysiological …

The intracellular calcium ions (Ca 2+) act as second messenger to regulate gene
transcription, cell proliferation, migration and death. Accumulating evidences have …

Valosin-containing protein (VCP)/p97, a member of the AAA+ ATPase family, is a molecular
chaperone recruited to the endoplasmic reticulum (ER) membrane by binding to membrane …

Cancer, the second cause of death worldwide, is characterized by several common criteria,
known as the “cancer hallmarks” such as unrestrained cell proliferation, cell death …

Ions are the cornerstones of various biological functions and have been widely used for
tumor therapy, called ion interference therapy (IIT). Calcium ion (Ca 2+) is one of the most …

Highlights•Discovery of new drugs against cancer is of utmost importance.•Drug repurposing
is an alternative approach to traditional drug discovery.•It significantly reduces the R&D …

Since the discovery of the participation of various ion channels in the regulation of cell
proliferation and programmed cell death two decades ago, the field exploring ion channel …

In their seminal papers Hanahan and Weinberg described oncogenic processes a normal
cell undergoes to be transformed into a cancer cell. The functions of ion channels in the …

Background There is a critical need to better understand the mechanisms that drive local cell
invasion and metastasis to develop new therapeutics targeting metastatic disease …

A major frontier in the post-genomic era is the investigation of the control of coordinated
growth and three-dimensional form. Dynamic remodeling of complex organs in regulative …