The decision to pursue one's desire for children is a basic human right. For transgender and
gender-diverse (TGD) people, gender-affirming care may alter the possibilities to fulfill one's …

The germline cells are essential for the propagation of human beings, thus essential for the
survival of mankind. The germline stem cells, as a unique cell type, generate various states …

Due to the growing number of young patients at risk of germ cell loss, there is a need to
preserve spermatogonial stem cells for patients who are not able to bank spermatozoa …

Fertility restoration in patients that survived a hematological cancer during childhood is a
core part of their care pathway. Nonetheless, there might be a risk of contamination of the …

STUDY QUESTION Twenty years after the inception of the first fertility preservation
programme for pre-pubertal boys, what are the current international practices with regard to …

Spermatogenesis refers to the differentiation of the spermatogonial stem cells (SSCs)
located in the base seminiferous tubules into haploid spermatozoa. Prerequisites for in vitro …

With advances in cancer treatment, such as cytotoxic chemotherapy and radiotherapy, grave
new sequelae of treatment have emerged for young cancer survivors. One sequela that …

Background Cryostorage of spermatogonial stem cells (SSCs) is an appropriate procedure
for long-term storage of SSCs for fertility preservation. However, it causes damage to cellular …

Male infertility is a major health problem affecting about 8–12% of couples worldwide.
Spermatogenesis starts in the early fetus and completes after puberty, passing through …

Traditional therapeutic interventions aim to restore male fertile potential or preserve sperm
viability in severe cases, such as semen cryopreservation, testicular tissue, germ cell …