Canonical Wnt signaling, which is transduced by β‐catenin and lymphoid enhancer factor
1/T cell‐specific transcription factors (LEF1/TCFs), regulates many aspects of metazoan …

Neurodevelopmental disorders (NDDs) include a large number of conditions such as Fragile
X syndrome, autism spectrum disorders and Down syndrome, among others. They are …

Background FOXP1 syndrome is an autosomal dominant neurodevelopmental disorder
characterized by intellectual disability, developmental delay, speech and language delays …

The human γ-aminobutyric acid (GABA) transporter 1 (hGAT-1) is the first member of the
solute carrier 6 (SLC6) protein superfamily. GAT-1 (SLC6A1) is one of the main GABA …

TCF7L2 encodes transcription factor 7‐like 2 (OMIM 602228), a key mediator of the
evolutionary conserved canonical Wnt signaling pathway. Although several large‐scale …

Intellectual disability (ID) is a pathological condition characterized by limited intellectual
functioning and adaptive behaviors. It affects 1–3% of the worldwide population, and no …

Simple Summary Fragile X syndrome (FXS) is a neurodevelopmental disorder and remains
the most frequent inherited cause of intellectual disability. Fragile X patients are at great risk …

Intellectual disabilities (ID) are a type of neurodevelopmental disorder (NDD). They can
have a genetic cause, including an emerging class of ID centring around Rho GTPases …

Abstract Background De novo mutations (DNMs) are variants that occur anew in the
offspring of noncarrier parents. They are not inherited from either parent but rather result …

MicroRNAs (or miRNAs) are short nucleotide sequences (~ 17–22 bp long) that play
important roles in gene regulation through targeting genes in the 3′ untranslated regions …