[HTML][HTML] The emerging roles of sphingosine 1-phosphate and SphK1 in cancer resistance: a promising therapeutic target

SS Alkafaas, MI Elsalahaty, DF Ismail… - Cancer Cell …, 2024 - Springer
Cancer chemoresistance is a problematic dilemma that significantly restrains numerous
cancer management protocols. It can promote cancer recurrence, spreading of cancer, and …

Mitochondrial influences on smooth muscle phenotype

WJ Pearce - American Journal of Physiology-Cell …, 2024 - journals.physiology.org
Smooth muscle cells transition reversibly between contractile and noncontractile
phenotypes in response to diverse influences, including many from mitochondria. Numerous …

Genomic, Transcriptomic, and Proteomic Depiction of Induced Pluripotent Stem Cells–Derived Smooth Muscle Cells As Emerging Cellular Models for Arterial …

L Liu, C Jouve, J Henry, TE Berrandou, JS Hulot… - …, 2023 - Am Heart Assoc
Background: Vascular smooth muscle cells (SMCs) plasticity is a central mechanism in
cardiovascular health and disease. We aimed at providing cellular phenotyping, epigenomic …

[HTML][HTML] Single cell RNA analysis uncovers the cell differentiation and functionalization for air breathing of frog lung

L Chang, Q Chen, B Wang, J Liu, M Zhang… - Communications …, 2024 - nature.com
The evolution and development of vertebrate lungs have been widely studied due to their
significance in terrestrial adaptation. Amphibians possess the most primitive lungs among …

Syntaxin4, P-cadherin, and CCAAT enhancer binding protein β as signaling elements in the novel differentiation pathway for cultured embryonic stem cells

S Matsuguchi, Y Hirai - Biochemical and Biophysical Research …, 2023 - Elsevier
Pluripotent stem cells possess the potential to differentiate into all three germ layers.
However, upon removal of the stemness factors, pluripotent stem cells, such as embryonic …

[HTML][HTML] Advances in exercise-induced vascular adaptation: mechanisms, models, and methods

H Sun, Y Zhang, L Shi - Frontiers in Bioengineering and …, 2024 - frontiersin.org
Insufficient physical activity poses a significant risk factor for cardiovascular diseases.
Exercise plays a crucial role in influencing the vascular system and is essential for …

[HTML][HTML] A Novel Gene List Identifies Tumors with a Stromal-Mesenchymal Phenotype and Worse Prognosis in Gastric Cancer

S Demirkol Canli, M Uner, B Kucukkaraduman… - Cancers, 2023 - mdpi.com
Simple Summary Gastric cancer is a leading cause of cancer-related death worldwide.
Despite developments in the clinical management of this disease, currently, only 31% of …

Inhibition of CIRBP represses the proliferation and migration of vascular smooth muscle cells via inhibiting Rheb/mTORC1 axis

J Zhao, C Qiu, R Wan, Q Wang, Y Zhang… - Biochemical and …, 2024 - Elsevier
The excessive migration and proliferation of vascular smooth muscle cells (VSMCs) plays a
vital role in vascular intimal hyperplasia. CIRBP is involved in the proliferation of various …

Early Growth Response-1: Friend or Foe in the Heart?

M Billah, A Naz, R Noor, R Bhindi… - Heart, Lung and …, 2023 - Elsevier
Cardiovascular disease is a major cause of mortality and morbidity worldwide. Early growth
response-1 (Egr-1) plays a critical regulatory role in a range of experimental models of …

The Role of FXR1 in Cell Cycle Control and the Induction of Senescence in Vascular Smooth Muscle

C Corbett - 2023 - search.proquest.com
Despite the advent of stents, intimal hyperplasia subsequent to vascular interventional
procedures remains a major obstacle. Vascular smooth muscle cells (VSMC) play a critical …