[HTML][HTML] The ABC subfamily A transporters: Multifaceted players with incipient potentialities in cancer
M Pasello, AM Giudice, K Scotlandi - Seminars in cancer biology, 2020 - Elsevier
Overexpression of ATP-binding cassette (ABC) transporters is a cause of drug resistance in
a plethora of tumors. More recent evidence indicates additional contribution of these …
a plethora of tumors. More recent evidence indicates additional contribution of these …
Is ABCA1 a lipid transfer protein?
MC Phillips - Journal of lipid research, 2018 - ASBMB
ABCA1 functions as a lipid transporter because it mediates the transfer of cellular
phospholipid (PL) and free (unesterified) cholesterol (FC) to apoA-I and related proteins …
phospholipid (PL) and free (unesterified) cholesterol (FC) to apoA-I and related proteins …
SOAT1 promotes mevalonate pathway dependency in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis, and new therapies are
needed. Altered metabolism is a cancer vulnerability, and several metabolic pathways have …
needed. Altered metabolism is a cancer vulnerability, and several metabolic pathways have …
Role of the steroidogenic acute regulatory protein in health and disease
PR Manna, CL Stetson, AT Slominski, K Pruitt - Endocrine, 2016 - Springer
Steroid hormones are an important class of regulatory molecules that are synthesized in
steroidogenic cells of the adrenal, ovary, testis, placenta, brain, and skin, and influence a …
steroidogenic cells of the adrenal, ovary, testis, placenta, brain, and skin, and influence a …
Liver X receptor β activation induces pyroptosis of human and murine colon cancer cells
V Derangere, A Chevriaux, F Courtaut… - Cell Death & …, 2014 - nature.com
Liver X receptors (LXRs) have been proposed to have some anticancer properties, through
molecular mechanisms that remain elusive. Here we report for the first time that LXR ligands …
molecular mechanisms that remain elusive. Here we report for the first time that LXR ligands …
Cholesterol metabolism in pathogenesis of osteoarthritis disease
Several lines of research indicate that osteoarthritis (OA) is not only a joint disorder
associated with mechanical stress and aging but also a 'metabolic syndrome'in which …
associated with mechanical stress and aging but also a 'metabolic syndrome'in which …
ABC transporters, mechanisms and biology: an overview
IB Holland - Essays in biochemistry, 2011 - portlandpress.com
This chapter concentrates mainly on structural and mechanistic aspects of ABC (ATP-
binding cassette) transporters and, as an example of the physiological significance of these …
binding cassette) transporters and, as an example of the physiological significance of these …
Cholesterol and male fertility: what about orphans and adopted?
S Maqdasy, M Baptissart, A Vega, S Baron… - Molecular and cellular …, 2013 - Elsevier
The link between cholesterol homeostasis and male fertility has been clearly suggested in
patients who suffer from hyperlipidemia and metabolic syndrome. This has been confirmed …
patients who suffer from hyperlipidemia and metabolic syndrome. This has been confirmed …
[HTML][HTML] Liver X receptor agonism sensitizes a subset of hepatocellular carcinoma to sorafenib by dual-inhibiting MET and EGFR
W Shao, W Zhu, J Lin, M Luo, Z Lin, L Lu, H Jia, L Qin… - Neoplasia, 2020 - Elsevier
Sorafenib is the first approved systemic therapy for advanced hepatocellular carcinoma
(HCC) and is the first-line choice in clinic. Sustained activation of receptor tyrosine kinases …
(HCC) and is the first-line choice in clinic. Sustained activation of receptor tyrosine kinases …
[HTML][HTML] Liver X receptor activation inhibits melanogenesis through the acceleration of ERK-mediated MITF degradation
CS Lee, M Park, J Han, J Lee, IH Bae, H Choi… - Journal of Investigative …, 2013 - Elsevier
Liver X receptors (LXRs) are nuclear receptors that act as ligand-activated transcription
factors regulating lipid metabolism and inflammation. In the skin, activation of LXRs …
factors regulating lipid metabolism and inflammation. In the skin, activation of LXRs …