Overexpression of ATP-binding cassette (ABC) transporters is a cause of drug resistance in
a plethora of tumors. More recent evidence indicates additional contribution of these …

ABCA1 functions as a lipid transporter because it mediates the transfer of cellular
phospholipid (PL) and free (unesterified) cholesterol (FC) to apoA-I and related proteins …

Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis, and new therapies are
needed. Altered metabolism is a cancer vulnerability, and several metabolic pathways have …

Steroid hormones are an important class of regulatory molecules that are synthesized in
steroidogenic cells of the adrenal, ovary, testis, placenta, brain, and skin, and influence a …

Liver X receptors (LXRs) have been proposed to have some anticancer properties, through
molecular mechanisms that remain elusive. Here we report for the first time that LXR ligands …

Several lines of research indicate that osteoarthritis (OA) is not only a joint disorder
associated with mechanical stress and aging but also a 'metabolic syndrome'in which …

This chapter concentrates mainly on structural and mechanistic aspects of ABC (ATP-
binding cassette) transporters and, as an example of the physiological significance of these …

The link between cholesterol homeostasis and male fertility has been clearly suggested in
patients who suffer from hyperlipidemia and metabolic syndrome. This has been confirmed …

Sorafenib is the first approved systemic therapy for advanced hepatocellular carcinoma
(HCC) and is the first-line choice in clinic. Sustained activation of receptor tyrosine kinases …

Liver X receptors (LXRs) are nuclear receptors that act as ligand-activated transcription
factors regulating lipid metabolism and inflammation. In the skin, activation of LXRs …