The mucosal immune system and IgA nephropathy

L Gesualdo, V Di Leo, R Coppo - Seminars in immunopathology, 2021 - Springer
The precise pathogenesis of immunoglobulin A nephropathy (IgAN) is still not clearly
established but emerging evidence confirms a pivotal role for mucosal immunity. This review …

Oral tolerance

AMC Faria, HL Weiner - Immunological reviews, 2005 - Wiley Online Library
Multiple mechanisms of tolerance are induced by oral antigen. Low doses favor active
suppression, whereas higher doses favor clonal anergy/deletion. Oral antigen induces T …

Oral tolerance: therapeutic implications for autoimmune diseases

AMC Faria, HL Weiner - Journal of Immunology Research, 2006 - Wiley Online Library
Oral tolerance is classically defined as the suppression of immune responses to antigens
(Ag) that have been administered previously by the oral route. Multiple mechanisms of …

Oral tolerance: mechanisms and therapeutic applications

AMC Faria, HL Weiner - Advances in immunology, 1999 - Elsevier
Publisher Summary This chapter discusses the mechanisms and therapeutic applications of
oral tolerance. The most striking characteristic of the gut mucosa is the abundance of the …

IgA nephropathy and infections

C Rollino, G Vischini, R Coppo - Journal of nephrology, 2016 - Springer
In this paper we concentrate on the role of infections in IgA nephropathy both from a
pathogenetic and clinic point of view. The current hypotheses as regards the role of …

The gut–kidney axis in IgA nephropathy: role of microbiota and diet on genetic predisposition

R Coppo - Pediatric nephrology, 2018 - Springer
Recent data suggest that gut-associated lymphoid tissue (GALT) plays a major role in the
development of immunoglobulin A (IgA) nephropathy (IgAN). A genome-wide association …

The intestine–renal connection in IgA nephropathy

R Coppo - Nephrology Dialysis Transplantation, 2015 - academic.oup.com
It is commonly stated that mucosal immunity plays a role in the pathogenesis of IgA
nephropathy (IgAN); however, the search for specific eliciting factors has been largely …

A new vision of IgA nephropathy: the missing link

F Sallustio, C Curci, V Di Leo, A Gallone… - International journal of …, 2019 - mdpi.com
IgA Nephropathy (IgAN) is a primary glomerulonephritis problem worldwide that develops
mainly in the 2nd and 3rd decade of life and reaches end-stage kidney disease after 20 …

The pathogenesis of IgA nephropathy: what is new and how does it change therapeutic approaches?

J Floege - American journal of kidney diseases, 2011 - Elsevier
Immunoglobulin A (IgA) nephropathy is the most common glomerulonephritis worldwide. For
example, in Japan, full-blown IgA nephropathy has been detected in∼ 1.5% of all allograft …

Oral tolerance

W Strober, B Kelsall, T Marth - Journal of clinical immunology, 1998 - Springer
Oral tolerance is the immunologic mechanism by which the mucosal immune system
maintains unresponsiveness to the myriad of antigens in the mucosal environment which …