Cancer development involves both genetic and epigenetic alterations. Aberrant epigenetic
modifications are reversible, allowing excellent opportunities for therapeutic intervention …

Multiple myeloma (MM) is a malignant hematological disease. The disease is characterized
by the clonal proliferation of malignant plasma cells in the bone marrow. MM accounts for …

Callicarpa longissima has been used as a Yao folk medicine to treat arthritis for years in
China, although its active anti-arthritic moieties have not been clarified so far. In this study …

Globally, malignancies cause one out of six mortalities, which is a serious health problem.
Cancer therapy has always been challenging, apart from major advances in …

Epigenetic changes play a significant role in cancer progression, maintenance and therapy
resistance. Generally, epigenetic modifications are reversible, thereby gaining attention for …

Abstract Background Even though numerous Histone deacetylase inhibitors (HDACi) have
been approved for the treatment of different types of cancer, and others are in clinical trials …

DNA methylation is one of the most studied epigenetic mechanisms that play a pivotal role in
regulating gene expression. The epigenetic component is strongly involved in aging-bone …

Diabetes represents a major health problem, involving a severe imbalance of blood sugar
levels, which can disturb the nerves, eyes, kidneys, and other organs. Diabes management …

D-type cyclins encode G1/S cell cycle checkpoint proteins, which play a crucial role in
defining cell cycle exit and progression. Precise control of cell cycle exit is vital during …

Mammalian DNA methyltransferases (DNMTs), including DNMT1, DNMT3A, and DNMT3B,
are key DNA methylation enzymes and play important roles in gene expression regulation …