Metabolism of cancer cells is geared toward biomass production and proliferation. Since the
metabolic resources within the local tissue are finite, this can lead to nutrient depletion and …

The hallmark of tumorigenesis is the successful circumvention of cell death regulation for
achieving unlimited replication and immortality. Ferroptosis is a newly identified type of cell …

Cell death can be executed through different subroutines. Since the description of
ferroptosis as an iron-dependent form of non-apoptotic cell death in 2012, there has been …

The cystine/glutamate antiporter SLC7A11 (also commonly known as xCT) functions to
import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in …

Background & Aims Hepatocellular carcinoma (HCC), a leading cause of cancer-related
death, is associated with viral hepatitis, non-alcoholic steatohepatitis (NASH), and alcohol …

The amino acid antiporter system Xc− is important for the synthesis of glutathione (GSH) that
functions to prevent lipid peroxidation and protect cells from nonapoptotic, iron-dependent …

Erastin was initially discovered as a small molecule compound that selectively kills tumor
cells expressing ST and RASV12 and was later widely investigated as an inducer of …

Cancer cells often upregulate nutrient transporters to fulfill their increased biosynthetic and
bioenergetic needs, and to maintain redox homeostasis. One nutrient transporter frequently …

Ferroptosis is a recently identified, iron-regulated, non-apoptotic form of cell death. It is
characterized by cellular accumulation of lipid reactive oxygen species that ultimately leads …

System xc− cystine/glutamate antiporter, composed of a light-chain subunit (xCT, SLC7A11)
and a heavy-chain subunit (CD98hc, SLC3A2), is mainly responsible for the cellular uptake …