SUMOylation promotes targeting of HP1α to pericentric heterochromatin. Here we identify
the SUMO-specific protease SENP7 in mouse as a maintenance factor for HP1α …

ABSTRACT Heterochromatin protein 1 (HP1) was initially discovered as a protein that is
associated with the heterochromatin at the chromocenter of polytene chromosomes in …

Locus control regions (LCRs) are gene regulatory elements in mammals that can overcome
the highly repressive effects normally associated with heterochromatic transgene locations …

Pericentric heterochromatin (PCH) is a particular form of constitutive heterochromatin that is
localized to both sides of centromeres and that forms silent compartments enriched in …

Publisher Summary This chapter describes that the problems relating to the organization of
heterochromatin are prominent in the general thinking about the organization of genetic …

We have compared the distribution of endogenous heterochromatin protein 1 (HP1) proteins
(α, β and γ) in different epithelial lines, pluripotent stem cells and embryonic fibroblasts. In …

Polycomb (Pc) is involved in the stable and heritable repression of homeotic gene activity
during Drosophila development. Here, we report the identification of a novel human Pc …

In order to survive, cells have evolved highly effective repair mechanisms to deal with the
potentially lethal DNA damage produced by exposure to endogenous as well as exogenous …

Background Selective gene silencing is key to development. It is generally accepted that
H3K27me3-enriched heterochromatin maintains transcriptional repression established …

Position-effect variegation in Drosophila, the mosaic expression of genes juxtaposed to
heterochromatin, remains an enigmatic long-range phenomenon. While the chromatin …