The emergence of Zika virus and its new clinical syndromes

TC Pierson, MS Diamond - Nature, 2018 - nature.com
Zika virus (ZIKV) is a mosquito-transmitted flavivirus that has emerged as a global health
threat because of its potential to generate explosive epidemics and ability to cause …

Immune response to dengue and Zika

A Elong Ngono, S Shresta - Annual review of immunology, 2018 - annualreviews.org
Flaviviruses such as dengue (DENV), yellow fever (YFV), West Nile (WNV), and Zika (ZIKV)
are human pathogens of global significance. In particular, DENV causes the most prevalent …

Pathogenesis of Zika virus infection

MI Giraldo, M Gonzalez-Orozco… - Annual Review of …, 2023 - annualreviews.org
Zika virus (ZIKV) is an emerging virus from the Flaviviridae family that is transmitted to
humans by mosquito vectors and represents an important health problem. Infections in …

Animal models in biological and biomedical research-experimental and ethical concerns

ML Andersen, LMF Winter - Anais da Academia Brasileira de Ciências, 2017 - SciELO Brasil
Animal models have been used in experimental research to increase human knowledge
and contribute to finding solutions to biological and biomedical questions. However …

Current status of Zika virus vaccines: successes and challenges

A Pattnaik, BR Sahoo, AK Pattnaik - Vaccines, 2020 - mdpi.com
The recently emerged Zika virus (ZIKV) spread to the Americas, causing a spectrum of
congenital diseases including microcephaly in newborn and Guillain-Barré syndrome (GBS) …

Zika vaccine development: current status

GA Poland, IG Ovsyannikova, RB Kennedy - Mayo Clinic Proceedings, 2019 - Elsevier
Zika virus outbreaks have been explosive and unpredictable and have led to significant
adverse health effects—as well as considerable public anxiety. Significant scientific work …

Evolution of two major Zika virus lineages: implications for pathology, immune response, and vaccine development

JT Beaver, N Lelutiu, R Habib, I Skountzou - Frontiers in immunology, 2018 - frontiersin.org
Zika virus (ZIKV) became a public health emergency of global concern in 2015 due to its
rapid expansion from French Polynesia to Brazil, spreading quickly throughout the …

Zika virus vaccine development: progress in the face of new challenges

MS Diamond, JE Ledgerwood… - Annual review of …, 2019 - annualreviews.org
Zika virus (ZIKV) emerged at a global level when it spread to the Americas and began
causing congenital malformations and microcephaly in 2015. A rapid response by …

Progress and works in progress: update on flavivirus vaccine development

MH Collins, SW Metz - Clinical therapeutics, 2017 - Elsevier
Most areas of the globe are endemic for at least one flavivirus, putting billions at risk for
infection. This diverse group of viral pathogens causes a range of manifestations in humans …

CD8+ T Cell Immune Response in Immunocompetent Mice during Zika Virus Infection

H Huang, S Li, Y Zhang, X Han, B Jia, H Liu… - Journal of …, 2017 - Am Soc Microbiol
Zika virus (ZIKV) infection causees neurologic complications, including Guillain-Barré
syndrome in adults and central nervous system (CNS) abnormalities in fetuses. We …