Opiates are among the oldest medications available to manage a number of medical
problems. Although pain is the current focus, early use initially focused upon the treatment of …

Management of Opioid Analgesic Overdose | New England Journal of Medicine Skip to main
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Morphine is an alkaloid from the opium poppy used to treat pain. The potentially lethal side
effects of morphine and related opioids—which include fatal respiratory depression—are …

Opium is one of the world's oldest drugs, and its derivatives morphine and codeine are
among the most used clinical drugs to relieve severe pain. These prototypical opioids …

The opioid crisis represents a major worldwide public health crisis that has accelerated the
search for safer and more effective opioids. Over the past few years, the identification of …

It is hard to decide when and where the opium poppy was first cultivated. It may have been
grown for its seeds before people discovered how to prepare mekonion from the leaves and …

▪ Abstract Opioid receptors belong to the large superfamily of seven transmembrane-
spanning (7TM) G protein-coupled receptors (GPCRs). As a class, GPCRs are of …

Opioids are used for pain management despite the side effects that contribute to the opioid
crisis. The pursuit of non-addictive opioid analgesics remains unattained due to the …

Publisher Summary Turns are a fundamental class of polypeptide structure and are defined
as sites where the peptide chain reverses its overall direction. In the past 20 years, the …

The opioid system modulates several physiological processes, including analgesia, the
stress response, the immune response and neuroendocrine function. Pharmacological and …