Significance: Chronic kidney disease (CKD) can be regarded as a burden of lifestyle
disease that shares common underpinning features and risk factors with the aging process; …

Dyslipidemia is a common nutritional and metabolic disorder in patients with chronic kidney
disease. Accumulating evidence supports the hypothesis that prolonged metabolic …

Parkinson's disease (PD) is a common age-related neurodegenerative disorder whose
pathogenesis is not completely understood. Mitochondrial dysfunction and increased …

Podocytes are a crucial cellular component in maintaining the glomerular filtration barrier,
and their injury is the major determinant in the development of albuminuria and diabetic …

Membrane-bound organelles in eukaryotic cells form an interactive network to coordinate
and facilitate cellular functions. The formation of close contacts, termed “membrane contact …

Growing evidence indicates that oxidative and endoplasmic reticular stress, which trigger
changes in ion channels and inflammatory pathways that may undermine cellular …

Obstructive nephropathy favors the progression to chronic kidney disease (CKD), a severe
health problem worldwide. The unilateral ureteral obstruction (UUO) model is used to study …

Diabetic kidney disease (DKD) is a major cause of end-stage kidney disease, and it is
crucial to understand the pathophysiology of DKD. The control of blood glucose levels by …

The endoplasmic reticulum (ER) plays important roles in biosynthetic and metabolic
processes, including protein and lipid synthesis, Ca2+ homeostasis regulation, and …

Both endoplasmic reticulum (ER) stress and autophagy have been implicated in chronic
kidney injury and renal fibrosis. However, the relationship and regulatory mechanisms …