Objective: To summarize current antibiotic dosing recommendations in critically ill patients
receiving intermittent hemodialysis (IHD), prolonged intermittent renal replacement therapy …

There is controversy over whether traditional intermittent bolus dosing or continuous infusion
of beta-lactam antibiotics is preferable in critically ill patients. No significant difference …

Introduction Altered pharmacokinetics (PK) in critically ill patients can result in insufficient
serum β-lactam concentrations when standard dosages are administered. Previous studies …

OBJECTIVES: To investigate the prevalence of potential drug interactions at the intensive
care unit of a university hospital in Brazil and to analyze their clinical significance …

Abstract Sepsis-Associated Acute Kidney Injury is a life-threatening condition leading to high
morbidity and mortality in critically ill patients admitted to the intensive care unit. Over the …

Antimicrobial resistance (AMR) is a major threat to global health due to the wide use of
antibacterial drugs. Multiple studies show that the pharmacokinetic/pharmacodynamic …

Background: The pharmacokinetics, especially the volume of distribution (Vd), of ß-lactam
antibiotics can be altered in critically ill patients. This can lead to decreased serum …

Linezolid is the first oxazolidinone agent introduced into clinical practice for use against
Gram-positive bacteria that are resistant to β-lactams and glycopeptides, including …

Empirically prescribed standard dosing regimens of antibacterial agents may result in
insufficient or excess plasma concentrations with persistently poor clinical outcomes …

Objective The purpose of the study was to determine the optimal dosing regimen of
intravenous fosfomycin for the treatment of Pseudomonas aeruginosa (PA) based on PK/PD …