Enhanced transforming growth factor (TGF)‐β signaling contributes to idiopathic pulmonary
fibrosis (IPF), a progressive and fatal disease characterized by alveolar epithelial type II …

Fibrosis or scarring of diverse organs and tissues is considered as a pathologic
consequence of a chronically altered wound healing response which is tightly linked to …

Most chronic liver diseases of all etiologies result in progressive liver fibrosis. Myofibroblasts
produce the extracellular matrix, including type I collagen, which constitutes the fibrous scar …

Rationale: Interferon-γ-inducible protein (IP)-10/CXCL10, an angiostatic and antifibrotic
chemokine with an important role in T-cell trafficking, is markedly induced in myocardial …

Idiopathic pulmonary fibrosis (IPF) is a highly heterogeneous and fatal disease. However,
IPF treatment has been limited by the low drug delivery efficiency to lungs and dysfunctional …

The development of cancer immunotherapies has been guided by advances in our
understanding of the dynamics between tumor cells and immune populations. An emerging …

Lung immunopathology is the main cause of influenza-mediated morbidity and death, and
much of its molecular mechanisms remain unclear. Whereas tumor necrosis factor-α (TNF-α) …

Pulmonary fibrosis is characterized by chronic inflammation and excessive collagen
deposition. Neutrophils are thought to be involved in the pathogenesis of lung fibrosis. We …

Mechanical force significantly modulates both inflammation and fibrosis, yet the fundamental
mechanisms that regulate these interactions remain poorly understood. Here we performed …

Background Several studies have implicated viral infection as an important factor in the
pathogenesis of IPF and related fibrotic lung disorders. Viruses are thought to cause …