Background In obesity, impaired adipose tissue function may promote secondary disease
through ectopic lipid accumulation and excess release of adipokines, resulting in systemic …

Objectives. To measure serum levels of CXCL10 and CCL2 chemokines in patients with
SSc, and relate the findings to clinical phenotype and disease progression. Methods. Serum …

Asthma is characterized by the association of airway hyperresponsiveness (AHR),
inflammation, and remodelling. The aim of the present article is to review the pivotal role of …

The impact of bone morphogenetic protein receptor 2 (BMPR2) gene mutations on vascular
remodelling in pulmonary arterial hypertension (PAH) is unknown. We sought to identify a …

Chemokines and their receptors play important roles in the pathophysiology of many
diseases by regulating the cellular migration of major inflammatory and immune players …

Chemokines are a family of small heparin-binding proteins, mostly known for their role in
inflammation and immune surveillance, which have emerged as important regulators of …

CD45+ and collagen I–positive (Col+) fibrocytes are implicated in fibrogenesis in skin, lungs,
and kidneys. Fibrocyte migration in response to liver injury was investigated using bone …

IL-22 has emerged as a crucial cytokine mediating protective response against pathogens
and tissue regeneration. Dysregulated production of IL-22 has been shown to play a pivotal …

Phosphatase and tensin homologue deleted from chromosome 10 (Pten) is expressed
aberrantly in non–small cell lung cancer cells, but the role of Pten in lung neoplasia has not …

Chemokine–glycosaminoglycan (GAG) interactions are thought to result in the formation of
tissue-bound chemokine gradients. We hypothesized that the binding of chemokines to …