Mu opioid receptor agonists are among the most powerful analgesic medications but also
among the most addictive. The current opioid crisis has energized a quest to develop opioid …

Opiates are among the oldest medications available to manage a number of medical
problems. Although pain is the current focus, early use initially focused upon the treatment of …

This classic text gives a uniquely lucid and lively view of neurotransmitters, their role in
nervous system function, and their involvement in the mechanisms of psychiatric drug action …

We present a systematic study for numerical atomic basis orbitals ranging from H to Kr,
which could be used in large scale O (N) electronic structure calculations based on density …

The molecular and cellular actions of three classes of abused drugs—opiates,
psychostimulants, and ethanol—are reviewed in the context of behavioral studies of drug …

Infants 18 to 20 weeks old recognize the correspondence between auditorially and visually
presented speech sounds, and the spectral information contained in the sounds is critical to …

The use of opioid analgesics has a long history in clinical settings, although the
comprehensive action of opioid receptors is still less understood. Nonetheless, recent …

Stress is a complex experience that carries both aversive and motivating properties. Chronic
stress causes an increase in the risk of depression, is well known to increase relapse of drug …

Salvia divinorum, whose main active ingredient is the neoclerodane diterpene Salvinorin A,
is a hallucinogenic plant in the mint family that has been used in traditional spiritual …

In the guinea pig ileum myenteric plexus—longitudinal muscle preparation, dynorphin-(1—
13) and the prototypical κ agonist ethylketocyclazocine had equally poor sensitivity to …