[HTML][HTML] Diagnosis and management of infections caused by multidrug-resistant bacteria: guideline endorsed by the Italian Society of Infection and Tropical Diseases …

G Tiseo, G Brigante, DR Giacobbe, AE Maraolo… - International Journal of …, 2022 - Elsevier
Management of patients with infections caused by multidrug-resistant organisms is
challenging and requires a multidisciplinary approach to achieve successful clinical …

A guide to therapeutic drug monitoring of β‐lactam antibiotics

AJ Fratoni, DP Nicolau, JL Kuti - Pharmacotherapy: The Journal …, 2021 - Wiley Online Library
Therapeutic drug monitoring (TDM) opens the door to personalized medicine, yet it is
infrequently applied to β‐lactam antibiotics, one of the most commonly prescribed drug …

[HTML][HTML] Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a …

S Hagel, F Bach, T Brenner, H Bracht… - Intensive Care …, 2022 - Springer
Purpose Insufficient antimicrobial exposure is associated with worse outcomes in sepsis. We
evaluated whether therapeutic drug monitoring (TDM)-guided antibiotic therapy improves …

The effect of renal replacement therapy and antibiotic dose on antibiotic concentrations in critically ill patients: data from the multinational sampling antibiotics in renal …

JA Roberts, GM Joynt, A Lee, G Choi… - Clinical Infectious …, 2021 - academic.oup.com
Background The optimal dosing of antibiotics in critically ill patients receiving renal
replacement therapy (RRT) remains unclear. In this study, we describe the variability in RRT …

[HTML][HTML] Recommendation of antimicrobial dosing optimization during continuous renal replacement therapy

L Li, X Li, Y Xia, Y Chu, H Zhong, J Li, P Liang… - Frontiers in …, 2020 - frontiersin.org
Continuous Renal Replacement Therapy (CRRT) is more and more widely used in patients
for various indications recent years. It is still intricate for clinicians to decide a suitable …

Meropenem versus piperacillin-tazobactam for definitive treatment of bloodstream infections caused by AmpC β-lactamase–producing Enterobacter spp, Citrobacter …

AG Stewart, DL Paterson, B Young… - Open forum …, 2021 - academic.oup.com
Background Carbapenems are recommended treatment for serious infections caused by
AmpC-producing gram-negative bacteria but can select for carbapenem resistance …

[HTML][HTML] Expert clinical pharmacological advice may make an antimicrobial TDM program for emerging candidates more clinically useful in tailoring therapy of critically …

M Gatti, PG Cojutti, M Bartoletti, T Tonetti, A Bianchini… - Critical Care, 2022 - Springer
Background Therapeutic drug monitoring (TDM) may represent an invaluable tool for
optimizing antimicrobial therapy in septic patients, but extensive use is burdened by barriers …

[HTML][HTML] Optimizing antimicrobial drug dosing in critically ill patients

P Póvoa, P Moniz, JG Pereira, L Coelho - Microorganisms, 2021 - mdpi.com
A fundamental step in the successful management of sepsis and septic shock is early
empiric antimicrobial therapy. However, for this to be effective, several decisions must be …

[HTML][HTML] Beta-lactams toxicity in the intensive care unit: an underestimated collateral damage?

C Roger, B Louart - Microorganisms, 2021 - mdpi.com
Beta-lactams are the most commonly prescribed antimicrobials in intensive care unit (ICU)
settings and remain one of the safest antimicrobials prescribed. However, the misdiagnosis …

Antimicrobial stewardship

C Lanckohr, H Bracht - Current Opinion in Critical Care, 2022 - journals.lww.com
Antimicrobial stewardship : Current Opinion in Critical Care Antimicrobial stewardship : Current
Opinion in Critical Care Log in or Register Subscribe to journalSubscribe Get new issue …