Mechanisms of SNARE proteins in membrane fusion
R Jahn, DC Cafiso, LK Tamm - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are a
family of small conserved eukaryotic proteins that mediate membrane fusion between …
family of small conserved eukaryotic proteins that mediate membrane fusion between …
Making the cut: Multiscale simulation of membrane remodeling
J Beiter, GA Voth - Current Opinion in Structural Biology, 2024 - Elsevier
Biological membranes are dynamic heterogeneous materials, and their shape and
organization are tightly coupled to the properties of the proteins in and around them …
organization are tightly coupled to the properties of the proteins in and around them …
[HTML][HTML] Modeling membranes in situ
CM Brown, SJ Marrink - Current Opinion in Structural Biology, 2024 - Elsevier
Molecular dynamics simulations of cellular membranes have come a long way—from simple
model lipid bilayers to multicomponent systems capturing the crowded and complex nature …
model lipid bilayers to multicomponent systems capturing the crowded and complex nature …
[HTML][HTML] Setting the curve: the biophysical properties of lipids in mitochondrial form and function
K Venkatraman, CT Lee, I Budin - Journal of Lipid Research, 2024 - Elsevier
Mitochondrial membranes are defined by their diverse functions, complex geometries, and
unique lipidomes. In the inner mitochondrial membrane (IMM), highly-curved membrane …
unique lipidomes. In the inner mitochondrial membrane (IMM), highly-curved membrane …
Building complex membranes with Martini 3
The Martini model is a popular force field for coarse-grained simulations. Membranes have
always been at the center of its development, with the latest version, Martini 3, showing great …
always been at the center of its development, with the latest version, Martini 3, showing great …
[HTML][HTML] Synaptotagmin 7 C2 domains induce membrane curvature stress via electrostatic interactions and the wedge mechanism
Abstract Synaptotagmin 7 (Syt-7) is part of the synaptotagmin protein family that regulates
exocytotic lipid membrane fusion. Among the family, Syt-7 stands out by its membrane …
exocytotic lipid membrane fusion. Among the family, Syt-7 stands out by its membrane …
Lipid Redistribution due to a Cell-Cell Fusion Pore
DW Allender, M Schick - Biophysical Journal, 2024 - cell.com
We consider the redistribution of lipids comprising the plasma membranes during cell-cell
fusion, particularly due to the presence of a fusion pore. Assuming the membranes are of …
fusion, particularly due to the presence of a fusion pore. Assuming the membranes are of …
Dynamic framework for large-scale modeling of membranes and peripheral proteins
M Sadeghi, D Rosenberger - Methods in enzymology, 2024 - pubmed.ncbi.nlm.nih.gov
In this chapter, we present a novel computational framework to study the dynamic behavior
of extensive membrane systems, potentially in interaction with peripheral proteins, as an …
of extensive membrane systems, potentially in interaction with peripheral proteins, as an …
Computing the influence of lipids and lipid complexes on membrane mechanics
A Hossein, K Sapp, A Sodt - Methods in enzymology, 2024 - pubmed.ncbi.nlm.nih.gov
Methodology for extracting the spontaneous curvature, bending modulus, and neutral
surface of a lipid bilayer is described. The" SPEX" method is a robust technique for …
surface of a lipid bilayer is described. The" SPEX" method is a robust technique for …
Membrane free-energy landscapes derived from atomistic dynamics explain nonuniversal cholesterol-induced stiffening
G Fiorin, LR Forrest, JD Faraldo-Gómez - PNAS nexus, 2023 - academic.oup.com
All lipid membranes have inherent morphological preferences and resist deformation. Yet
adaptations in membrane shape can and do occur at multiple length scales. While this …
adaptations in membrane shape can and do occur at multiple length scales. While this …