Survivin, an inhibitor of apoptosis (IAP) containing one baculovirus IAP repeat (BIR) domain,
has been reported to be capable of regulating both cellular proliferation and apoptotic cell …

Bcl-2/adenovirus E1B 19 kDa-interacting protein 3 (BNIP3) is a mitochondrial pro-apoptotic
protein that has a single Bcl-2 homology 3 (BH3) domain and a COOH-terminal …

Altered expression of apoptosis-regulating genes plays an important role in the aggressive
growth behavior and chemoresistance of pancreatic ductal adenocarcinoma. In the present …

Fluorouracil (5-FU), together with other drugs such as oxaliplatin, is one of the most
important pharmacological agents in the treatment of colorectal cancer. Although mitogen …

Xanthohumol (XN) is one of the major prenylflavonoids found in hop cones (Humulus
lupulus L.). In this study, we investigated the cell growth inhibitory potential of XN on cultured …

A facile method for generation of tumor spheroids in large quantity with controllable size and
high uniformity is presented. HCT-116 cells are used as a model cell line. Individual tumor …

The isothiocyanates sulforaphane and PEITC (β-phenethyl isothiocyanate) as well as the
indoles indole-3-carbinol and its condensation product 3, 3′-diindolylmethane are known …

Iron is critical for cell growth and proliferation. Iron chelators are being explored for a number
of clinical applications, including the treatment of neurodegenerative disorders, heart …

Tumor acidosis is associated with increased invasiveness and drug resistance. Here, we
take an unbiased approach to identify vulnerabilities of acid-exposed cancer cells by …

Chemotherapy in drug-resistant cancers remains a challenge. Owing to associated poor
bioavailability, oral administration of hydrophobic anticancer drugs like paclitaxel has been …