Mitochondrial oxidative stress—a causative factor and therapeutic target in many diseases

P Kowalczyk, D Sulejczak, P Kleczkowska… - International journal of …, 2021 - mdpi.com
The excessive formation of reactive oxygen species (ROS) and impairment of defensive
antioxidant systems leads to a condition known as oxidative stress. The main source of free …

Closing the loop for patients with Parkinson disease: where are we?

H Teymourian, F Tehrani, K Longardner… - Nature Reviews …, 2022 - nature.com
Although levodopa remains the most efficacious symptomatic therapy for Parkinson disease
(PD), management of levodopa treatment during the advanced stages of the disease is …

The understanding of Parkinson's disease through genetics and new therapies

O Uwishema, H Onyeaka, R Badri, AN Yücel… - Brain and …, 2022 - Wiley Online Library
Introduction Parkinson's disease is one of the progressive neurodegenerative diseases from
which people suffer for years. The mechanism of this disease is associated with a decrease …

Iron metabolism in aging and age-related diseases

Y Tian, Y Tian, Z Yuan, Y Zeng, S Wang, X Fan… - International journal of …, 2022 - mdpi.com
Iron is a trace metal element necessary to maintain life and is also involved in a variety of
biological processes. Aging refers to the natural life process in which the physiological …

Telomerase reverse transcriptase and neurodegenerative diseases

X Yu, MM Liu, CY Zheng, YT Liu, Z Wang… - Frontiers in …, 2023 - frontiersin.org
Neurodegenerative diseases (NDs) are chronic conditions that result in progressive damage
to the nervous system, including Alzheimer's disease (AD), Parkinson's disease (PD) …

Post treatment with Gastrodin suppresses oxidative stress and attenuates motor disorders following 6-OHDA induced Parkinson disease

Z Sadeghian, S Eyvari-Brooshghalan, M Sabahi… - Neuroscience …, 2022 - Elsevier
Background & objective Researchers are currently trying to find new therapies with better
symptomatic activity and fewer side effects to manage Parkinson's disease (PD). Although …

Neuroprotection against aminochrome neurotoxicity: Glutathione transferase M2-2 and DT-diaphorase

J Segura-Aguilar, P Muñoz, J Inzunza, M Varshney… - Antioxidants, 2022 - mdpi.com
Glutathione is an important antioxidant that plays a crucial role in the cellular protection
against oxidative stress and detoxification of electrophilic mutagens, and carcinogens …

[HTML][HTML] Integrating virtual reality and exergaming in cognitive rehabilitation of patients with Parkinson disease: a systematic review of randomized controlled trials

N Marotta, D Calafiore, C Curci, L Lippi… - EuropEan Journal of …, 2022 - ncbi.nlm.nih.gov
CONCLUSIONS Exergaming and VR might be considered promising rehabilitation
interventions in the cognitive rehabilitation framework of PD patients. Further high-quality …

Interventions to improve gait in Parkinson's disease: a systematic review of randomized controlled trials and network meta-analysis

VS Hvingelby, AN Glud, JCH Sørensen, Y Tai… - Journal of …, 2022 - Springer
Introduction Disabling gait symptoms, especially freezing of gait (FoG), represents a
milestone in the progression of Parkinson's disease (PD). This systematic review and …

Functionalized hydrogels in neural injury repairing

W Zhao, H Tu, J Chen, J Wang, H Liu… - Frontiers in …, 2023 - frontiersin.org
Repairing injuries to the nervous system has always been a prominent topic in clinical
research. Direct suturing and nerve displacement surgery are the primary treatment options …