Molecular, cellular, morphological, physiological and behavioral aspects of gonadotropin-inhibitory hormone

T Ubuka, YL Son, K Tsutsui - General and comparative endocrinology, 2016 - Elsevier
Gonadotropin-inhibitory hormone (GnIH) is a hypothalamic neuropeptide that was isolated
from the brains of Japanese quail in 2000, which inhibited luteinizing hormone release from …

Central and peripheral neuropeptide RFRP-3: a bridge linking reproduction, nutrition, and stress response

P Singh, S Anjum, RK Srivastava, K Tsutsui… - Frontiers in …, 2022 - Elsevier
This article is an amalgamation of the current status of RFRP-3 (GnIH) in reproduction and
its association with the nutrition and stress-mediated changes in the reproductive activities …

[HTML][HTML] Aging and chronic administration of serotonin-selective reuptake inhibitor citalopram upregulate Sirt4 gene expression in the preoptic area of male mice

DW Wong, T Soga, IS Parhar - Frontiers in genetics, 2015 - frontiersin.org
Sexual dysfunction and cognitive deficits are markers of the aging process. Mammalian
sirtuins (SIRT), encoded by sirt 1-7 genes, are known as aging molecules which are …

RFamide peptides as mediators in environmental control of GnRH neurons

I Parhar, S Ogawa, T Kitahashi - Progress in Neurobiology, 2012 - Elsevier
Hypothalamic gonadotropin-releasing hormone (GnRH) is a key hormone for reproductive
functions in vertebrates and non-vertebrates. Although GnRH neuronal system is regulated …

[HTML][HTML] Reproductive neuroendocrine pathways of social behavior

IS Parhar, S Ogawa, T Ubuka - Frontiers in endocrinology, 2016 - frontiersin.org
Social behaviors are key components of reproduction, because they are essential for
successful fertilization. Social behaviors, such as courtship, mating, and aggression, are …

Recent studies of gonadotropin-inhibitory hormone (GnIH) in the mammalian hypothalamus, pituitary and gonads

GE Bentley, K Tsutsui, LJ Kriegsfeld - Brain research, 2010 - Elsevier
The hypothalamo-pituitary-gonadal (HPG) axis integrates internal and external cues via a
balance of stimulatory and inhibitory neurochemical systems to time reproductive activity …

Endocrine disruption as an adverse effect of non-endocrine targeting pharmaceuticals

S Sabir, MF Akhtar, A Saleem - Environmental Science and Pollution …, 2019 - Springer
Endocrine disruptors have gained widespread attention owing to their severe adverse
health impacts. These produce enormous burden of disease and are associated with high …

[HTML][HTML] Structural and functional divergence of gonadotropin-inhibitory hormone from jawless fish to mammals

S Ogawa, IS Parhar - Frontiers in Endocrinology, 2014 - frontiersin.org
Gonadotropin-inhibitory hormone (GnIH) was discovered as a novel hypothalamic peptide
that inhibits gonadotropin release in the quail. The presence of GnIH-homologous peptides …

A novel herbal treatment reduces depressive-like behaviors and increases BDNF levels in the brain of stressed mice

R Doron, D Lotan, N Einat, R Yaffe, A Winer, I Marom… - Life sciences, 2014 - Elsevier
Aims Depression is a chronic, recurring and potentially life-threatening illness. Current
treatments for depression are characterized by a low success rate and associated with a …

Neuropeptide AF induces anxiety-like and antidepressant-like behavior in mice

M Palotai, G Telegdy, M Tanaka, Z Bagosi… - Behavioural brain …, 2014 - Elsevier
Little is known about the action of neuropeptide AF (NPAF) on anxiety and depression. Only
our previous study provides evidence that NPAF induces anxiety-like behavior in rats …