The epithelial-mesenchymal transition and the cytoskeleton in bioengineered systems

SE Leggett, AM Hruska, M Guo, IY Wong - Cell Communication and …, 2021 - Springer
The epithelial-mesenchymal transition (EMT) is intrinsically linked to alterations of the
intracellular cytoskeleton and the extracellular matrix. After EMT, cells acquire an elongated …

Physical and chemical gradients in the tumor microenvironment regulate tumor cell invasion, migration, and metastasis

MJ Oudin, VM Weaver - Cold Spring Harbor symposia on …, 2016 - symposium.cshlp.org
Cancer metastasis requires the invasion of tumor cells into the stroma and the directed
migration of tumor cells through the stroma toward the vasculature and lymphatics where …

Flexible patch with printable and antibacterial conductive hydrogel electrodes for accelerated wound healing

C Wang, X Jiang, HJ Kim, S Zhang, X Zhou, Y Chen… - Biomaterials, 2022 - Elsevier
Electrical stimulation can facilitate wound healing with high efficiency and limited side
effects. However, current electrical stimulation devices have poor conformability with …

Electrotaxis evokes directional separation of co-cultured keratinocytes and fibroblasts

J Leal, S Shaner, N Jedrusik, A Savelyeva… - Scientific Reports, 2023 - nature.com
Bioelectric communication plays a significant role in several cellular processes and
biological mechanisms, such as division, differentiation, migration, cancer metastasis, and …

Recent developments in microfluidics-based chemotaxis studies

J Wu, X Wu, F Lin - Lab on a Chip, 2013 - pubs.rsc.org
Microfluidic devices can better control cellular microenvironments compared to conventional
cell migration assays. Over the past few years, microfluidics-based chemotaxis studies …

Self-regulatory micro-and macroscale patterning of ATP-mediated nanobioconjugate

E Shandilya, S Maiti - ACS nano, 2023 - ACS Publications
Directional interactions and the assembly of a nanobioconjugate in clusters at a specific
location are important for patterning and microarrays in biomedical research. Herein, we …

Electric field stimulation for tissue engineering applications

CNM Ryan, MN Doulgkeroglou, DI Zeugolis - BMC Biomedical …, 2021 - Springer
Electric fields are involved in numerous physiological processes, including directional
embryonic development and wound healing following injury. To study these processes in …

Microfluidics for studying metastatic patterns of lung cancer

M Ruzycka, MR Cimpan, I Rios-Mondragon… - Journal of …, 2019 - Springer
The incidence of lung cancer continues to rise worldwide. Because the aggressive
metastasis of lung cancer cells is the major drawback of successful therapies, the crucial …

Overriding native cell coordination enhances external programming of collective cell migration

G Shim, D Devenport… - Proceedings of the …, 2021 - National Acad Sciences
As collective cell migration is essential in biological processes spanning development,
healing, and cancer progression, methods to externally program cell migration are of great …

Microfluidic co-culture system for cancer migratory analysis and anti-metastatic drugs screening

S Mi, Z Du, Y Xu, Z Wu, X Qian, M Zhang, W Sun - Scientific reports, 2016 - nature.com
Tumour metastasis is an important reason for cancer death, and cancer cell migration is an
important step in the process of tumour metastasis. Studying cancer cell migration is of great …