JCVI-syn3A is a genetically minimal bacterial cell, consisting of 493 genes and only a single
543 kbp circular chromosome. Syn3A's genome and physical size are approximately one …

Faithful replication and maintenance of the genome are essential to the ability of any
organism to survive and propagate. For an obligate pathogen such as Mycobacterium …

The maintenance and organization of the chromosome plays an important role in the
development and survival of bacteria. Bacterial chromatin proteins are architectural proteins …

Deinococcus radiodurans is a spherical bacterium well-known for its outstanding resistance
to DNA-damaging agents. Exposure to such agents leads to drastic changes in the …

Mesoscale molecular modeling is providing a new window into the inner workings of living
cells. Modeling of genomes, however, remains a technical challenge, due to their large size …

ParA and ParB homologs are involved in accurate chromosome segregation in bacteria.
ParBs participate in the separation of ori domains by binding to parS palindromes, mainly …

Nucleoid‐associated proteins (NAPs) in bacteria contribute to key activities such as DNA
compaction, chromosome organization and regulation of gene expression. HU and Lsr2 are …

Bacteria evolve as a result of mutations and acquisition of foreign DNA by recombination
processes. A growing body of evidence suggests that mutation and recombination rates are …

The packaging of DNA into chromosomes is a ubiquitous process that enables living
organisms to structure and transmit their genome accurately through cell divisions. In the …

The higher order organization of eukaryotic and prokaryotic genomes is pivotal in the
regulation of gene expression. Specifically, chromatin accessibility in eukaryotes and …