Engineering precision nanoparticles for drug delivery

MJ Mitchell, MM Billingsley, RM Haley… - Nature reviews drug …, 2021 - nature.com
In recent years, the development of nanoparticles has expanded into a broad range of
clinical applications. Nanoparticles have been developed to overcome the limitations of free …

Immunomodulatory nanosystems

X Feng, W Xu, Z Li, W Song, J Ding… - Advanced science, 2019 - Wiley Online Library
Immunotherapy has emerged as an effective strategy for the prevention and treatment of a
variety of diseases, including cancer, infectious diseases, inflammatory diseases, and …

Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases

S Ji, M Xiong, H Chen, Y Liu, L Zhou, Y Hong… - … and Targeted Therapy, 2023 - nature.com
The ageing process is a systemic decline from cellular dysfunction to organ degeneration,
with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells …

Pemphigus: a comprehensive review on pathogenesis, clinical presentation and novel therapeutic approaches

R Pollmann, T Schmidt, R Eming, M Hertl - Clinical reviews in allergy & …, 2018 - Springer
Pemphigus is a group of rare, potentially devastating autoimmune diseases of the skin and
mucous membranes with high morbidity and potentially lethal outcome. The major clinical …

[HTML][HTML] Bacterial outer membrane vesicles-based therapeutic platform eradicates triple-negative breast tumor by combinational photodynamic/chemo …

Y Li, J Wu, X Qiu, S Dong, J He, J Liu, W Xu, S Huang… - Bioactive Materials, 2023 - Elsevier
Bacterial outer membrane vesicles (OMVs) are potent immuno-stimulating agents and have
the potentials to be bioengineered as platforms for antitumor nanomedicine. In this study …

Improving vaccine and immunotherapy design using biomaterials

ML Bookstaver, SJ Tsai, JS Bromberg, CM Jewell - Trends in immunology, 2018 - cell.com
Polymers, lipids, scaffolds, microneedles, and other biomaterials are rapidly emerging as
technologies to improve the efficacy of vaccines against infectious disease and …

[HTML][HTML] Pre-clinical and clinical implications of “inside-out” vs.“outside-in” paradigms in multiple sclerosis etiopathogenesis

HE Titus, Y Chen, JR Podojil, AP Robinson… - Frontiers in cellular …, 2020 - frontiersin.org
Multiple Sclerosis (MS) is an immune-mediated neurological disorder, characterized by
central nervous system (CNS) inflammation, oligodendrocyte loss, demyelination, and …

[HTML][HTML] Nanoparticles for the induction of antigen-specific immunological tolerance

TK Kishimoto, RA Maldonado - Frontiers in immunology, 2018 - frontiersin.org
Antigen-specific immune tolerance has been a long-standing goal for immunotherapy for the
treatment of autoimmune diseases and allergies and for the prevention of allograft rejection …

Use of polymeric nanoparticle platform targeting the liver to induce treg-mediated antigen-specific immune tolerance in a pulmonary allergen sensitization model

Q Liu, X Wang, X Liu, S Kumar, G Gochman, Y Ji… - ACS …, 2019 - ACS Publications
Nanoparticles (NPs) can be used to accomplish antigen-specific immune tolerance in
allergic and autoimmune disease. The available options for custom-designing tolerogenic …

Mechanistic contributions of Kupffer cells and liver sinusoidal endothelial cells in nanoparticle-induced antigen-specific immune tolerance

LM Casey, KR Hughes, MN Saunders, SD Miller… - Biomaterials, 2022 - Elsevier
The intravenous delivery of disease-relevant antigens (Ag) by polymeric nanoparticles (NP-
Ags) has demonstrated Ag-specific immune tolerance in autoimmune and allergic disorders …