By shaping T cell immunity, tolerogenic dendritic cells (tDCs) play critical roles in the
induction of immune tolerance after transplantation. However, the role of long noncoding …

The intravenous delivery of disease-relevant antigens (Ag) by polymeric nanoparticles (NP-
Ags) has demonstrated Ag-specific immune tolerance in autoimmune and allergic disorders …

Autoimmune diseases, such as celiac disease, multiple sclerosis, and type 1 diabetes, are
leading causes of morbidity and mortality in the United States. In these disease states …

Developing biomaterials to control the responsiveness of innate immune cells represents a
clinically relevant approach to treat diseases with an underlying inflammatory basis, such as …

Polymeric nanoparticles (NPs) have demonstrated their potential to induce antigen (Ag)-
specific immunological tolerance in multiple immune models and are at various stages of …

Vaccines and immunotherapies have provided enormous improvements for public health,
but there are fundamental disconnects between where most studies are performed—in cell …

Cancer virotherapy is a paradigm-shifting treatment modality based on virus-mediated
oncolysis and subsequent antitumor immune responses. Clinical trials of currently available …

Immunomodulation, manipulation of the immune responses towards an antigen, is a
promising strategy to treat cancer, infectious diseases, allergies, and autoimmune diseases …

Inflammation is a key homeostatic process involved in the body's response to a multitude of
disease states including infection, autoimmune disorders, cancer, and other chronic …

Current strategies for treating autoimmunity involve the administration of broad-acting
immunosuppressive agents that impair healthy immunity. Intravenous (iv) administration of …