Nanoparticle dose and antigen loading attenuate antigen‐specific T‐cell responses
Immune‐mediated hypersensitivities such as autoimmunity, allergy, and allogeneic graft
rejection are treated with therapeutics that suppress the immune system, and the lack of …
rejection are treated with therapeutics that suppress the immune system, and the lack of …
[HTML][HTML] Immune tolerance induced by immune-homeostatic particles
Autoimmune diseases, induced by dysfunction of the adaptive immune system, are the
common disease categories worldwide. Recently, regulatory T cells (Tregs) enhancing …
common disease categories worldwide. Recently, regulatory T cells (Tregs) enhancing …
Repurposing the cardiac glycoside digoxin to stimulate myelin regeneration in chemically‐induced and immune‐mediated mouse models of multiple sclerosis
Multiple sclerosis (MS) is a central nervous system (CNS) autoimmune disease
characterized by inflammation, demyelination, and neurodegeneration. The ideal MS …
characterized by inflammation, demyelination, and neurodegeneration. The ideal MS …
Lymph node-targeted synthetically glycosylated antigen leads to antigen-specific immunological tolerance
Inverse vaccines that tolerogenically target antigens to antigen-presenting cells (APCs) offer
promise in prevention of immunity to allergens and protein drugs and treatment of …
promise in prevention of immunity to allergens and protein drugs and treatment of …
Arrest in the Progression of Type 1 Diabetes at the Mid-Stage of Insulitic Autoimmunity Using an Autoantigen-Decorated All-trans Retinoic Acid and Transforming …
BE Phillips, Y Garciafigueroa, C Engman… - Frontiers in …, 2021 - frontiersin.org
Type 1 diabetes (T1D) is a disorder of impaired glucoregulation due to lymphocyte-driven
pancreatic autoimmunity. Mobilizing dendritic cells (DC) in vivo to acquire tolerogenic …
pancreatic autoimmunity. Mobilizing dendritic cells (DC) in vivo to acquire tolerogenic …
Advances in immunotherapy of type I diabetes
Type 1 diabetes mellitus (T1DM) is an autoimmune disease affecting 3 million individuals in
the US The pathogenesis of T1DM is driven by immune-mediated destruction of pancreatic β …
the US The pathogenesis of T1DM is driven by immune-mediated destruction of pancreatic β …
Biomaterial-driven immunomodulation: cell biology-based strategies to mitigate severe inflammation and sepsis
JJM Lasola, H Kamdem, MW McDaniel… - Frontiers in …, 2020 - frontiersin.org
Inflammation is an essential component of a wide variety of disease processes and
oftentimes can increase the deleterious effects of a disease. Finding ways to modulate this …
oftentimes can increase the deleterious effects of a disease. Finding ways to modulate this …
Tolerogenic nanoparticles impacting B and T lymphocyte responses delay autoimmune arthritis in K/BxN mice
A Srivastava, BM Arlian, L Pang… - ACS chemical …, 2021 - ACS Publications
Current treatments for unwanted antibody responses largely rely on immunosuppressive
drugs compromising overall immunity. New approaches to achieve antigen-specific …
drugs compromising overall immunity. New approaches to achieve antigen-specific …
Biohybrid nanoparticles to negotiate with biological barriers
Incapability of effective cross‐talk with biological environments has partly impaired the in
vivo functionality of nanoparticles (NPs). Homing, biodistribution, and function of NPs could …
vivo functionality of nanoparticles (NPs). Homing, biodistribution, and function of NPs could …
Using gold nanoparticles for enhanced intradermal delivery of poorly soluble auto-antigenic peptides
RK Singh, C Malosse, J Davies, B Malissen… - … , Biology and Medicine, 2021 - Elsevier
Abstract Ultra-small 1-2 nm gold nanoparticles (NP) were conjugated with a poorly-soluble
peptide auto-antigen, associated with type 1 diabetes, to modify the peptide …
peptide auto-antigen, associated with type 1 diabetes, to modify the peptide …