Engineering nanoparticle therapeutics for food allergy

LM Rad, G Arellano, JR Podojil, JJ O'Konek… - Journal of Allergy and …, 2023 - Elsevier
Food allergy is a growing public health issue among children and adults that can lead to life-
threatening anaphylaxis following allergen exposure. The criterion standard for disease …

Masked delivery of allergen in nanoparticles safely attenuates anaphylactic response in murine models of peanut allergy

KR Hughes, MN Saunders, JJ Landers… - Frontiers in …, 2022 - frontiersin.org
Food allergy is a growing health concern worldwide. Current allergen-specific
immunotherapy (AIT) approaches require frequent dosing over extended periods of time and …

The impact of nanocarriers in the induction of antigen-specific immunotolerance in autoimmune diseases

F Dangkoub, M Sankian, M Tafaghodi… - Journal of Controlled …, 2021 - Elsevier
Immunotolerance induction in an antigen-specific manner is the long-term goal of
immunotherapy to treat autoimmune diseases. Nanocarriers (NCs) can be designed as a …

Autoantigen-specific immune tolerance in pathological and physiological cell death: Nanotechnology comes into view

A Tajbakhsh, N Farahani, SM Gheibihayat… - International …, 2021 - Elsevier
Apoptotic cells are tolerogenic and can present self-antigens in the absence of inflammation,
to antigen-presenting cells by the process of efferocytosis, resulting in anergy and depletion …

Tip-concentrated microneedle patch delivering everolimus for therapy of multiple sclerosis

Y Yang, W Song, N Wang, Y Ren, H Liu - Biomaterials advances, 2022 - Elsevier
Multiple sclerosis is a chronic progressive demyelinating disease of the central nervous
system. At present, systemic drug therapy for multiple sclerosis has limited efficacy and …

Administration of ROS-Scavenging Cerium Oxide Nanoparticles Simply Mixed with Autoantigenic Peptides Induce Antigen-Specific Immune Tolerance against …

TL Nguyen, NM Phan, J Kim - ACS Applied Materials & Interfaces, 2024 - ACS Publications
The scavenging ability of cerium oxide nanoparticles (CeNPs) for reactive oxygen species
has been intensively studied in the field of catalysis. However, the immunological impact of …

[HTML][HTML] Micro/nanostructured topography on titanium orchestrates dendritic cell adhesion and activation via β2 integrin-FAK signals

Y Yang, Y Lin, R Xu, Z Zhang, W Zeng… - International Journal of …, 2022 - ncbi.nlm.nih.gov
Background and Purpose In clinical application of dental implants, the functional state of
dendritic cells (DCs) has been suggested to have a close relationship with the implant …

Immunogenic cell death (ICD) of murine H22 cells induced by lentinan

W Wang, X Yang, C Li, Y Li, H Wang, X Han - Nutrition and Cancer, 2022 - Taylor & Francis
Lentinan can lead to apoptosis of tumor cells and improve immune function. However,
limited research focused on the immunogenic death regulation mechanism of lentinan on …

Lipid–Polymer Hybrid Nanoparticles Utilize B Cells and Dendritic Cells to Elicit Distinct Antigen-Specific CD4+ and CD8+ T Cell Responses

MH Zhang, BL Scotland, Y Jiao, EM Slaby… - ACS Applied Bio …, 2023 - ACS Publications
Antigen-presenting cells (APCs) are widely studied for treating immune-mediated diseases,
and dendritic cells (DCs) are potent APCs that uptake and present antigens (Ags). However …

Integration of islet/beta-cell transplants with host tissue using biomaterial platforms

DW Clough, JL King, F Li, LD Shea - Endocrinology, 2020 - academic.oup.com
Cell-based therapies are emerging for type I diabetes mellitus (T1D), an autoimmune
disease characterized by the destruction of insulin-producing pancreatic β-cells, as a means …