Reinstating tissue-specific tolerance has attracted much attention as a means to treat
autoimmune diseases. However, despite promising results in rodent models of autoimmune …

As an important part of the immune system, T lymphocytes exhibit undoubtedly an important
role in targeting and eradicating cancer. However, despite these characteristics, their natural …

Therapies for autoimmune diseases such as multiple sclerosis and diabetes are not curative
and cause significant challenges for patients. These include frequent, continued treatments …

Memory T cells respond rapidly in part because they are less reliant on a heightened levels
of costimulatory molecules. This enables rapid control of secondary infecting pathogens but …

Tolerogenic dendritic cells (tDCs) induces regulatory T cell (Treg) differentiation and
promotes immune tolerance. However, the effective generation of tDCs in vivo to treat …

Type 1 diabetes (T1D) is an autoimmune disease caused by the destruction of pancreatic β
cells by autoantigen‐reactive diabetogenic cells. Antigen‐specific therapies using islet …

Polymers are widely used in pharmaceutical formulations and drug delivery systems across
length scales (macro-, micro-, and nano-systems). Miniaturization of such systems could …

T cell adaptation is an important peripheral tolerogenic process which ensures that the T cell
population can respond effectively to pathogens but remains tolerant to self‐antigens. We …

Autoimmune responses to aquaporin 4 (AQP4) cause neuromyelitis optica (NMO); thus,
specific immunotolerance to this self-antigen could represent a new NMO treatment. We …

Purpose The immunomodulatory effects of thalidomide (TM) and dexamethasone (DX) on
immune cells and their co-stimulatory, co-inhibitory molecules in vitro and in vivo have been …